Article (Scientific journals)
Targeting cholesterol homeostasis to fight hearing loss: a new perspective.
Malgrange, Brigitte; Varela-Nieto, Isabel; de Medina, Philippe et al.
2015In Frontiers in Aging Neuroscience, 7, p. 3
Peer Reviewed verified by ORBi
 

Files


Full Text
frontiers (2015) - malgrange.PDF
Publisher postprint (764.46 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
cholesterol homeostasis; excitotoxicity; liver X receptor; oxysterol; sensorineural hearing loss
Abstract :
[en] Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions. The pathophysiological mechanisms involved in SNHL include oxidative stress, excitotoxicity, inflammation, and ischemia, resulting in synaptic loss, axonal degeneration, and apoptosis of spiral ganglion neurons. The mechanisms associated with SNHL are shared with other neurodegenerative disorders. Cholesterol homeostasis is central to numerous pathologies including neurodegenerative diseases and cholesterol regulates major processes involved in neurons survival and function. The role of cholesterol homeostasis in the physiopathology of inner ear is largely unexplored. In this review, we discuss the findings concerning cholesterol homeostasis in neurodegenerative diseases and whether it should be translated into potential therapeutic strategies for the treatment of SNHL.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Biochemistry, biophysics & molecular biology
Author, co-author :
Malgrange, Brigitte  ;  Université de Liège > GIGA - Neurosciences
Varela-Nieto, Isabel
de Medina, Philippe
Paillasse, Michael R.
Language :
English
Title :
Targeting cholesterol homeostasis to fight hearing loss: a new perspective.
Publication date :
2015
Journal title :
Frontiers in Aging Neuroscience
eISSN :
1663-4365
Publisher :
Frontiers Media S.A., Switzerland
Volume :
7
Pages :
3
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 304900 - AFHELO - Preclinical proof of concept of AF243 potency to prevent and/or treat sensorineural hearing loss
Funders :
CE - Commission Européenne [BE]
Available on ORBi :
since 12 June 2015

Statistics


Number of views
68 (4 by ULiège)
Number of downloads
138 (2 by ULiège)

Scopus citations®
 
27
Scopus citations®
without self-citations
25
OpenCitations
 
23

Bibliography


Similar publications



Contact ORBi