[fr] Le lupus érythémateux disséminé (LED) est une maladie de système aux conséquences aussi multiples qu’invalidantes. La prévalence des épisodes dépressifs majeurs y est significativement supérieure à celle des sujets sains ou atteints d’autres pathologies inflammatoires. S’il est évident que le statut de maladie chronique au dénouement souvent péjoratif et le nombre de traitements qu’elle impose constituent des facteurs favorisants, il est probable que les mécanismes pathogéniques du LED occasionnent une atteinte cérébrale précipitant une symptomatologie dépressive. Cet article approfondit les liens entre LED et dépression à travers des notions épidémiologiques, étiopathogéniques et thérapeutiques.
Disciplines :
Psychiatry Urology & nephrology General & internal medicine
Author, co-author :
Lemaire, Benoît ; Université de Liège - ULiège > 1re an. master compl. méd. urg. (complet - 6ans)
Geron, Donatienne ; Université de Liège - ULiège > 1re an. master compl. méd. gén. (formation 2 ans)
MALAISE, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Krzesinski, Jean-Marie ; Université de Liège > Département des sciences cliniques > Néphrologie
Ansseau, Marc ; Université de Liège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Scantamburlo, Gabrielle ; Université de Liège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Language :
French
Title :
La dépression est une complication fréquente du lupus érythémateux disséminé : considérations épidémiologiques, pathogéniques et thérapeutiques
Alternative titles :
[en] Depression as a common complication of systemic lupus
Publication date :
April 2015
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
70
Issue :
4
Pages :
215-218
Peer reviewed :
Peer reviewed
Commentary :
Systemic lupus erythematosus (SLE) is an inflammatory disease with multiple and disabling consequences,
including the psychological status. The prevalence of major depressive episodes among patients suffering from SLE is
significantly higher than in healthy people, or people suffering from other inflammatory diseases. While it is obvious that its chronic disease status with a frequently pejorative ending, as well as the number of treatments it requires, are contributing factors, it is likely that due to its pathogenic mechanisms, SLE causes direct injury to the brain, leading to a depressive symptomatology. Numerous hypotheses are under consideration.
We shall review them all, recall a few epidemiologic features, add histology and medical imaging contributions and
discuss the importance of setting up a fitting therapy for such patients.
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