[en] This SELEX experiment, for the selection of HER2 targeting aptamers, resulted in 26 selected RNA aptamers for further individual evaluation. Up till now, we
were able to identify two aptamers that show binding to HER2 overexpressing SK-OV-3 cancer cells. In addition, we were able to generate silenced SK-OV-3
cells with minimal remaining HER2 levels, which will be used to obtain more information regarding the binding specificity of the selected aptamers.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gijs, Marlies ; Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, An
Impens, Nathalie
Baatout, Sarah
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Language :
English
Title :
Development of aptamer-based radiopharmaceuticals for targeted cancer imaging and therapy
Publication date :
04 March 2013
Event name :
First Symposium on Precision Image-Guided Small Animal RadioTherapy
