[en] In this study, different techniques were evaluated to test the binding properties of an anti-HER3 aptamer to its target on cells or as pure protein. Furthermore, the aptamer was successfully coupled to DOTA-NHS ester and labelled with natural occurring lutetium. However, for a better yield, the coupling and labelling reactions need further optimization.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gijs, Marlies ; Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, An; Belgian Nuclear Research Centre, SCK•CEN > Radiobiology Unit
Impens, Nathalie; Belgian Nuclear Research Centre, SCK•CEN > Radiobiology Unit
Baatout, Sarah; Belgian Nuclear Research Centre, SCK-CEN > Radiobiology Unit
Dewilde, Sylvia; University of Antwerp > Department of Biomedical Sciences,
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Language :
English
Title :
Synthesis of lutetium-carrying oligonucleotides for targeted cancer therapy and imaging
