Poster (Scientific congresses and symposiums)
Regiospecific radiolabeling of Nanofitin on Ni Magnetic Beads with 18F-FBEM and in vivo PET studies
Dammicco, Sylvestre; Lemaire, Christian; Cinier, Mathieu et al.
2015International Symposium on Radiophamaceutical Siences
 

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Keywords :
Nanofitin; Radiolabeling; 18F
Abstract :
[en] Nanofitins(NFs) are a small, single chain and cysteine-free protein able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family and are highly stable over a wide range of pH (0-13) and temperature (Tm ~80°C). Their extreme stability, low cost and high tolerability for chemical coupling make NFs an interesting alternative to antibodies. The aim of this study was to develop the first synthesis of a radiolabeled NF since no in vivo biodistribution kinetic studies have been published.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Chemistry
Author, co-author :
Dammicco, Sylvestre ;  Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Other collaborator :
Lemaire, Christian ;  Université de Liège > Centre de recherches du cyclotron
Cinier, Mathieu
Plenevaux, Alain  ;  Université de Liège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Language :
English
Title :
Regiospecific radiolabeling of Nanofitin on Ni Magnetic Beads with 18F-FBEM and in vivo PET studies
Publication date :
May 2015
Event name :
International Symposium on Radiophamaceutical Siences
Event date :
du 26 au 31 mai 2015
Audience :
International
Available on ORBi :
since 05 June 2015

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