Reference : Individualizing treatment of type 2 diabetes by targeting postprandial or fasting hyp...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/182328
Individualizing treatment of type 2 diabetes by targeting postprandial or fasting hyperglycaemia: Response to a basal vs a premixed insulin regimen by HbA quartiles and ethnicity.
English
Scheen, André mailto [Université de Liège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques >]
Schmitt, H. [> >]
Jiang, H. H. [> >]
Ivanyi, T. [> >]
2015
Diabetes & metabolism
41
3
216-222
Yes (verified by ORBi)
International
1262-3636
1878-1780
[en] Basal insulin ; Ethnicity ; HbA(1c) ; Premixed insulin ; Type 2 diabetes
[en] AIM: This study evaluated the proportions of prandial (PHG) vs fasting hyperglycaemia (FHG) over 24h in a group of patients with type 2 diabetes (overall and for Caucasian vs Asian patients), and tested the hypothesis that an insulin regimen with a prandial component allows a greater response than basal insulin at low glycated haemoglobin (HbA1c) levels with a higher proportion of PHG than FHG. METHODS: Relative contributions of PHG and FHG to overall hyperglycaemia were analyzed by baseline HbA1c quartiles and by ethnicity at baseline and after 24-week treatment with either insulin glargine or insulin lispro mix 25 in the DURABLE study. RESULTS: With increasing baseline HbA1c, the mean relative contribution of PHG to the total area under the curve decreased (from 41% to 27%) while FHG was increased (from 59% to 73%). Both insulins decreased FHG, but only insulin lispro mix 25 decreased PHG. More patients with baseline HbA1c<9%, where PHG was more relevant, achieved the target HbA1c of<7% at endpoint with insulin lispro mix 25 compared with glargine. On average, Asians had a 10% larger contribution of PHG at all HbA1c quartiles, and a lower proportion of Asians reached the HbA1c target of<7% with either insulin treatment compared with Caucasians. CONCLUSION: At baseline, the contribution of FHG to overall hyperglycaemia predominated at all HbA1c quartiles, whereas PHG was more clinically relevant at lower HbA1c levels and with a greater response to insulin lispro mix 25. Asians had a greater proportion of PHG and a lesser response to either insulins compared with Caucasians. Thus, responses to diabetes drugs by baseline HbA1c and ethnicity are worth investigating to better target and individualize treatment.
Researchers ; Professionals
http://hdl.handle.net/2268/182328
Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
2015 Diab metab individualizing treatment of DT2.pdfPublisher postprint1.29 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.