Article (Scientific journals)
Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells.
Ali, Amjad; Shah, Abdus Saboor; Ahmad, Ayaz
2014In Cancer Letters
Peer Reviewed verified by ORBi
 

Files


Full Text
1-s2.0-S0304383514004248-main.pdf
Author preprint (1.08 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
mutant p53; klf17; metastasis
Abstract :
[en] Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT). However, its expression is downregulated in metastatic breast cancer that contains p53 mutations. Here, we show that mutant-p53 plays a key role to suppress KLF17 and thereby enhances cancer progression, which defines novel gain-of-function (GOF) of mutant-p53. Mutant-p53 interacts with KLF17 and antagonizes KLF17 mediated EMT genes transcription. Depletion of KLF17 promotes cell viability, decreases apoptosis and induces drug resistance in metastatic breast cancer cells. KLF17 suppresses cell migration and invasion by decreasing CD44, PAI-1 and Cyclin-D1 expressions. Taken together, our results show that KLF17 is important for the suppression of metastasis and could be a potential therapeutic target during chemotherapy.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Ali, Amjad ;  Université de Liège > Département de pharmacie > Chimie médicale
Shah, Abdus Saboor
Ahmad, Ayaz
Language :
English
Title :
Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells.
Publication date :
01 November 2014
Journal title :
Cancer Letters
ISSN :
0304-3835
eISSN :
1872-7980
Publisher :
Elsevier Science Ireland, Limerick, Ireland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 June 2015

Statistics


Number of views
34 (2 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
37
Scopus citations®
without self-citations
31
OpenCitations
 
32

Bibliography


Similar publications



Contact ORBi