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Biotechnological uses of RNAi in plants: Risk assessment considerations
Casacuberta, J. M.; Devos, Y.; du Jardin, Patrick et al.
2015In Trends in Biotechnology, 33 (3), p. 145-147
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Keywords :
Food/feed safety; Gene silencing; Genetically modified organism (GMO); Nontarget organism (NTO); Off-target gene; Plant breeding; Note; RNA interference
Abstract :
[en] RNAi offers opportunities to generate new traits in genetically modified (GM) plants. Instead of expressing novel proteins, RNAi-based GM plants reduce target gene expression. Silencing of off-target genes may trigger unintended effects, and identifying these genes would facilitate risk assessment. However, using bioinformatics alone is not reliable, due to the lack of genomic data and insufficient knowledge of mechanisms governing mRNA-small (s)RNA interactions. © 2014 Elsevier Ltd.
Disciplines :
Phytobiology (plant sciences, forestry, mycology...)
Biotechnology
Author, co-author :
Casacuberta, J. M.;  Center for Research in Agricultural Genomics, Consejo Superior de Investigaciones Científicas-Institut de Recerca i Tecnologia, Agroalimentàries-Universitat Autònoma de Barcelona-Universitat de Barcelona, Campus Universitat Autònoma de Barcelona, Bellaterra - Cerdanyola del Vallès, Barcelona, Spain
Devos, Y.;  European Food Safety Authority, Via Carlo Magno 1/A, Parma, Italy
du Jardin, Patrick  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie végétale
Ramon, M.;  European Food Safety Authority, Via Carlo Magno 1/A, Parma, Italy
Vaucheret, H.;  INRA, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France, AgroParisTech, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France
Nogué, F.;  INRA, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France, AgroParisTech, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France
Language :
English
Title :
Biotechnological uses of RNAi in plants: Risk assessment considerations
Publication date :
2015
Journal title :
Trends in Biotechnology
ISSN :
0167-7799
eISSN :
1879-3096
Publisher :
Elsevier
Volume :
33
Issue :
3
Pages :
145-147
Peer reviewed :
Peer Reviewed verified by ORBi
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since 28 May 2015

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