Reference : Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angioge...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/181994
Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment.
English
Suarez-Carmona, Meggy mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Bourcy, Morgane mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
LESAGE, J []
Leroi, Natacha mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Syne, Laidya [> >]
Blacher, Silvia mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Hubert, Pascale mailto [Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Erpicum, Charlotte mailto [Université de Liège > > R&D Direction : Chercheurs ULg en mobilité >]
Foidart, Jean-Michel mailto [Université de Liège > Département des sciences cliniques > Gynécologie - Obstétrique >]
Delvenne, Philippe mailto [Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Birembaut, Philippe [> >]
Noël, Agnès mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Polette, Myriam [> >]
Gilles, Christine mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
2015
Journal of Pathology (The)
John Wiley & Sons, Inc
236
4
491-504
Yes (verified by ORBi)
International
0022-3417
1096-9896
Chichester
United Kingdom
[en] angiogenesis ; cancer ; epithelial-to-mesenchymal transition ; myeloid cells
[en] Epithelial-to-mesenchymal transition (EMT) programs provide cancer cells with invasive and survival capacities that might favor metastatic dissemination. Whilst signaling cascades triggering EMT have been extensively studied, the impact of EMT on the crosstalk between tumor cells and the tumor microenvironment remains elusive. We aimed to identify EMT-regulated soluble factors that facilitate the recruitment of host cells in the tumor. Our findings indicate that EMT phenotypes relate to the induction of a panel of secreted mediators, namely IL-8, IL-6, sICAM-1, PAI-1 and GM-CSF, and implicate the EMT-transcription factor Snail as a regulator of this process. We further show that EMT-derived soluble factors are pro-angiogenic in vivo (in the mouse ear sponge assay), ex vivo (in the rat aortic ring assay) and in vitro (in a chemotaxis assay). Additionally, conditioned medium from EMT-positive cells stimulates the recruitment of myeloid cells. In a bank of 40 triple-negative breast cancers, tumors presenting features of EMT were significantly more angiogenic and infiltrated by a higher quantity of myeloid cells compared to tumors with little or no EMT. Taken together, our results show that EMT programs trigger the expression of soluble mediators in cancer cells that stimulate angiogenesis and recruit myeloid cells in vivo, which might in turn favor cancer spread.
http://hdl.handle.net/2268/181994
10.1002/path.4546
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