Article (Scientific journals)
Intensity of prolactinoma on T2-weighted magnetic resonance imaging: towards another gender difference.
KREUTZ, Julie; VROONEN, Laurent; Cattin, Françoise et al.
2015In Neuroradiology
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Abstract :
[en] INTRODUCTION: Clinical presentations of prolactinomas are quite different between genders. In comparison with women's prolactinoma, those in men showed predominance of large tumors with high prolactin (PRL) levels. This preponderance could be attributed to a greater proliferative potential of the tumors. Differences in magnetic resonance imaging (MRI) signal at diagnosis have not been yet clearly evaluated. METHODS: We conduct a retrospective study comparing MRI signal intensity (SI) on T2-weighted images (T2-WI) between 41 men and 41 women to investigate whether or not men prolactinoma present specific features. RESULTS: In addition to the size of the adenoma and PRL levels (P < 0001), prolactinomas in men also exhibit differences from those in women in signal on T2-WI on MRI (P < 0001). Women's prolactinomas are mostly of high SI on T2-WI while men's prolactinomas exhibit a more heterogeneous pattern of SI on T2-WI. Prolactinomas presenting with low SI on T2-WI are almost exclusively encountered in men. CONCLUSIONS: Presence of T2-WI hypointensities in pituitary adenoma can be predictive of a different subtype of prolactinoma almost encountered in men and possibly translate the presence of spherical amyloid deposits, in agreement with the literature.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
KREUTZ, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
VROONEN, Laurent ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Cattin, Françoise
PETROSSIANS, Patrick  ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
THIRY, Albert ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Rostomyan, Liliya  ;  Université de Liège - ULiège > Doct. sc. médicales (Bologne)
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Beckers, Albert ;  Université de Liège > Département des sciences cliniques > Endocrinologie
BONNEVILLE, Jean-François ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Language :
English
Title :
Intensity of prolactinoma on T2-weighted magnetic resonance imaging: towards another gender difference.
Publication date :
2015
Journal title :
Neuroradiology
ISSN :
0028-3940
eISSN :
1432-1920
Publisher :
Springer, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 May 2015

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