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Poster (Scientific congresses and symposiums)
Aliphatic polyphosphates: a promising family of polymers for drug delivery
Vanslambrouck, Stéphanie; Clement, Benoît; Riva, Raphaël et al.
2015Belgian Polymer Group (BPG) Annuel Meeting
 

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Keywords :
ring-opening polymerization (ROP); polyphosphate; micelle; biomaterial; nanomedicine
Abstract :
[en] Thanks to their biocompatibility and biodegradability, polyphosphates are appealing polymers for biomedical applications. In contrast to polyesters, polyphosphate properties and functionality are easily tuned via the chemical nature of the lateral chains. In this work, a series of amphiphilic PEO-block-polyphosphate copolymers were synthesized by organo-catalyzed ring-opening polymerization of cyclic phosphates. These polymers are directly dissolved in water in the absence of any organic solvent and they self-assemble to form nanoparticles Our work aims at changing the lateral chain of polyphosphates to investigate the influence of this structural modification on (i) the size of the nanoparticles, (ii) the critical aggregation concentration, (iii) the encapsulation of an hydrophobic drug in the core of the nanoparticles and, finally, (iv) the release of the drug.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Vanslambrouck, Stéphanie ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Clement, Benoît ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Riva, Raphaël ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Broze, Guy ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Préat, Véronique;  Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute, Pharmaceutics and Drug Deliv (LDRI)
Molin, Daniel G.;  Maastricht University, BioMIMedics Interreg EMR IV-A Consortium: Lead Partner
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lecomte, Philippe  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Aliphatic polyphosphates: a promising family of polymers for drug delivery
Publication date :
18 May 2015
Event name :
Belgian Polymer Group (BPG) Annuel Meeting
Event place :
Houffalize, Belgium
Event date :
18/05/2015 - 19/05/2015
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The "Interreg" BioMiMedics program
Commentary :
This poster was presented by Stéphanie Vanslambrouck
Available on ORBi :
since 26 May 2015

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