Article (Scientific journals)
Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area.
BULK, Saskia; Visser, O.; Rozendaal, L. et al.
2003In British Journal of Cancer, 89 (5), p. 834-9
Peer Reviewed verified by ORBi
 

Files


Full Text
Bulk 15.pdf
Publisher postprint (121.79 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adenocarcinoma/epidemiology/mortality/pathology; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Carcinoma, Squamous Cell/epidemiology/mortality/pathology; Female; Humans; Incidence; Mass Screening; Middle Aged; Neoplasm Staging; Netherlands/epidemiology; Prognosis; Survival Rate/trends; Uterine Cervical Neoplasms/epidemiology/mortality/pathology
Abstract :
[en] To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100,000 women in 1988 to 5.9/100,000 in 2000 (P<0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2-2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions.
Disciplines :
Genetics & genetic processes
Author, co-author :
BULK, Saskia ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Visser, O.
Rozendaal, L.
Verheijen, R. H. M.
Meijer, C. J. L. M.
Language :
English
Title :
Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area.
Publication date :
2003
Journal title :
British Journal of Cancer
ISSN :
0007-0920
eISSN :
1532-1827
Publisher :
Nature Publishing Group, United Kingdom
Volume :
89
Issue :
5
Pages :
834-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 May 2015

Statistics


Number of views
26 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
57
Scopus citations®
without self-citations
46
OpenCitations
 
44

Bibliography


Similar publications



Contact ORBi