[en] In previous works, poly(D,L-lactide-co-?CL-poly(ethylene glycol) (poly(D,L-La-co-?PEG?CL) amphiphilic graft- 10 copolymers were successfully synthesized according to a copper azide-alkyne cycloaddition (CuAAC) strategy. This paper aims 11 at reporting on the behavior of this amphiphilic copolymer in water, which was not studied in the previous paper. Moreover, 12 the ability of the copolymer to stabilize a PLA nanoparticles aqueous suspension is presented. For this purpose, dynamic 13 light scattering (DLS) and transmission electron microscopy (TEM) are proposed to characterize the nanoparticles in solution. 14 Otherwise, the strategy developed for the synthesis of the amphiphilic copolymers was adapted and extended to the synthesis of 15 PLA-based degradable hydrogel, potentially applicable as drug-loaded degradable polymer implant.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Riva, Raphaël ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Schmeits, Stéphanie; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Croisier, Florence ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lecomte, Philippe ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Poly(ethylene glycol) grafted polylactide based copolymers for the preparation of PLA-based nanocarriers and hybrid hydrogel
Publication date :
2015
Journal title :
Clinical Hemorheology and Microcirculation
ISSN :
1386-0291
Publisher :
IOS Press, Amsterdam, Netherlands
Volume :
60
Pages :
65-75
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique The Walloon Region (GGO6) in the frame of the project EMBIOSE
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