Reference : Strontium ranelate normalizes bone mineral density in osteopenic patients
Scientific journals : Article
Social & behavioral sciences, psychology : Sociology & social sciences
Human health sciences : Geriatrics
http://hdl.handle.net/2268/18134
Strontium ranelate normalizes bone mineral density in osteopenic patients
English
Malaise, Olivier mailto [Université de Liège - ULg > > > Cert.ECG]
Bruyère, Olivier mailto [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Aug-2007
Aging Clinical & Experimental Research
Editrice Kurtis S R L
19
4
330-333
Yes (verified by ORBi)
International
1594-0667
Milan
[en] bone mineral density ; osteopenia ; strontium ranelate
[en] AIMS: To assess the capacity of strontium ranelate to restore normal bone mineral density (WHO definition: T-score >or=-1) in post-menopausal osteopenic women (T-score between -1 and -2.5) at baseline. METHODS: Post-hoc analysis from SOTI and TROPOS studies of 1428 patients randomly assigned to receive either 2 g of strontium ranelate a day or placebo for three years. Bone mineral density was measured at baseline and each year for three years. Results were analyzed on an intention-to-treat basis. RESULTS: At lumbar spine, after one, two and three years of treatment with strontium ranelate, 26.4, 42.1 and 58.2% respectively of osteopenic patients normalized their bone mineral density, compared with 6.6, 8.9 and 11.9% in the placebo group (all p<0.001). At total hip, the percentage of patients normalizing their bone mineral density was 5.4, 10.0 and 19.6% in the strontium ranelate group and 1.8, 1.4 and 1.6% in the placebo one (all p<0.001). CONCLUSION: Strontium ranelate is able to normalize bone mineral density in a significant proportion of osteopenic patients after one, two and three years of treatment. The clinical relevance of these results should be confirmed by direct demonstration of the anti-fracture efficacy of strontium ranelate in osteopenic patients.
http://hdl.handle.net/2268/18134

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