Master’s dissertation (Dissertations and theses)
Intégration perceptive et mémoire épisodique dans la maladie d'Alzheimer
Delhaye, Emma
2014
 

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Keywords :
Episodic memory; Alzheimer's disease
Abstract :
[en] Binding (i.e., to link different components together) is a key mechanism for episodic memory formation. Normal aging is characterized by a decrease in episodic memory for associations. However, associative memory performance can be improved and age-related differences can even be suppressed when associations are unitized, that is when they are encoded as an integrated whole. A previous study in Alzheimer's disease (AD) showed that patients do not benefit from this particular type of encoding in episodic memory, so that their performance for unitized representations remains very poor. The aim of the current study was to assess whether the unitization mechanism itself (i.e., to integrate components into a whole) is impaired in AD or whether a global memory impairment affects all kinds of representations (unitized and non-unitized). We evaluated this hypothesis in fifteen mild Alzheimer patients and twenty healthy control participants. To systematically increase the demands on unitization, pictures of objects and animals were either left intact, separated into two fragments, or separated into four fragments. Participants viewed the pictures and had to unitize them first in order to recognize it and judge whether it would fit into a shoebox. In a subsequent recognition test where all pictures were intact, they had to retrieve pictures they saw earlier. An analysis of correct recognition of studied pictures showed a significant interaction between group and fragmentation level, indicating a decrease in Alzheimer patients’ performance compared to control participants for pictures that were fragmented at study but not for pictures that were intact at encoding. These findings suggest that the perceptual mechanism of unitization of fragmented stimuli is impaired in Alzheimer's disease.
Disciplines :
Neurosciences & behavior
Author, co-author :
Delhaye, Emma  ;  Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
French
Title :
Intégration perceptive et mémoire épisodique dans la maladie d'Alzheimer
Alternative titles :
[en] Perceptual integration and episodic memory in Alzheimer's disease
Defense date :
September 2014
Institution :
ULiège - Université de Liège
Degree :
Master en sciences psychologiques, à finalité spécialisée en neuroscience cognitive et comportementale
Promotor :
Collette, Fabienne  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Bastin, Christine  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Jury member :
Brédart, Serge ;  Université de Liège - ULiège > Département de Psychologie
Germain, Sophie ;  Université de Liège - ULiège > Département de Psychologie > Psychologie clinique de l'adulte
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since 07 May 2015

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