Reference : GCxGC-TOFMS and supervised multivariate approaches to study human cadaveric decomposi...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/180960
GCxGC-TOFMS and supervised multivariate approaches to study human cadaveric decomposition olfactive signatures
English
Stefanuto, Pierre-Hugues mailto [Université de Liège > Département de chimie (sciences) > Chimie analytique, organique et biologique >]
Perrault, Katelynn A. [University of Technology Sydney > Center for Forensic Science > > >]
Stadler, Sonja [University of Ontario Institute of Technology > Faculty of Science > > >]
Pesesse, Romain mailto [Université de Liège > Département de chimie (sciences) > Chimie analytique, organique et biologique >]
Leblanc, Helene N. [University of Ontario Institute of Technology > Faculty of Science > > >]
Forbes, Shari L. [University of Technology Sydney > Center for Forensic Science > > >]
Focant, Jean-François mailto [Université de Liège > Département de chimie (sciences) > Chimie analytique, organique et biologique >]
7-Apr-2015
Analytical Bioanalytical Chemistry
407
16
4767-4778
Yes (verified by ORBi)
International
1618-2642
1618-2650
Berlin
Germany
[en] Human decomposition ; GCxGC-TOFMS ; Victim recovery canines
[en] In forensic thanato-chemistry, the understanding ofthe process of soft tissue decomposition is still limited. Abetter understanding of the decomposition process and thecharacterization of the associated volatile organic compounds(VOC) can help to improve the training of victim recovery(VR) canines, which are used to search for trapped victimsin natural disasters or to locate corpses during criminal investigations.The complexity of matrices and the dynamic natureof this process require the use of comprehensive analyticalmethods for investigation. Moreover, the variability of theenvironment and between individuals creates additional difficultiesin terms of normalization. The resolution of the complexmixture of VOCs emitted by a decaying corpse can beimproved using comprehensive two-dimensional gas chromatography(GC× GC), compared to classical singledimensionalgas chromatography (1DGC). This study combinesthe analytical advantages of GC×GC coupled to timeof-flight mass spectrometry (TOFMS) with the data handlingrobustness of supervised multivariate statistics to investigatethe VOC profile of human remains during early stages ofdecomposition. Various supervised multivariate approachesare compared to interpret the large data set. Moreover, earlydecomposition stages of pig carcasses (typically used as humansurrogates in field studies) are also monitored to obtain adirect comparison of the two VOC profiles and estimate therobustness of this human decomposition analog model. In thisresearch, we demonstrate that pig and human decompositionprocesses can be described by the same trends for the majorcompounds produced during the early stages of soft tissuedecomposition.
Organic and Biological Analytical Chemistry Group
http://hdl.handle.net/2268/180960
10.1007/s00216-015-8683-5

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
10.1007_s00216-015-8683-5.pdfPublisher postprint1.68 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.