Autocrine role of TGFbeta1 in adrenal.

Adrenal Glands/chemistry/physiology; Animals; Gene Expression Regulation; Humans; Receptors, Angiotensin/genetics; Receptors, Corticotropin/genetics; Receptors, Transforming Growth Factor beta/analysis/physiology; Transforming Growth Factor beta/pharmacology/physiology

Abstract :

[en] Three main criteria are required to postulate that a factor has an autocrine action in any cell: presence of receptors and biological effects of the factor; local production which must be regulated by physiological signals and the inhibition of its secretion or action should cause effects opposite to those caused by the exogenous factor. In adrenal cells, transforming growth factor beta1 (TGFbeta1) fulfilled these criteria: 1) Adrenal cells possess TGFbeta1 receptors and this factor regulates the expression of adrenal cell specific genes, including ACTH and angiotensin II (AngII) receptors and several steroidogenic enzymes, leading to changes in the steroidogenic responsiveness; 2) Adrenal cells express and secrete TGFbeta1 and its secretion is regulated by the two adrenal specific hormones ACTH and AngII; 3) The blockade of TGFbeta1 protein synthesis by an antisense oligonucleotide produces changes in adrenal cell functions opposed to those induced by the exogenous factor.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Langlois, D.

Leroy, Céline ; Université de Liège > Département de langues et littératures modernes > Département de langues et littératures modernes

Penhoat, A.

LEBRETHON, Marie-Christine ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Saez, J. M.

Language :

English

Title :

Autocrine role of TGFbeta1 in adrenal.

Publication date :

1998

Journal title :

Hormone and Metabolic Research

ISSN :

0018-5043

eISSN :

1439-4286

Publisher :

Thieme, Stuttgart, Germany

Volume :

Issue :

6-7

Pages :

411-415

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 April 2015

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Bibliography

Penhoat A, Jaillard C, Saez JM. Corticotropin positively regulates its own receptors and cAMP response in cultured bovine adrenal cells. Proc Natl Acad Sci USA 1989; 86: 4978-81
Simpson ER, Waterman MR. Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 1988; 50: 427-40
Penhoat A, Jaillard C, Crozat A, Saez JM. Regulation of angiotensin II receptors and steroidogenic responsiveness in cultured bovine fasciculata and glomerulosa adrenal cells. Eur J Biochem 1988; 172: 247-54
Ouali R, Langlois D, Saez JM, Bégeot M. Opposite effects of angiotensin-II and corticotropin on bovine adrenocortical cell steroidogenic responsiveness. Mol Cell Endocrinol 1991; 81: 43-52
Hotta M, Baird A. Differential effects of transforming growth factor type β on the growth and function of adrenocortical cells in vitro. Proc Nat Acad Sci USA 1986; 83: 7795-9
Feige JJ, Cochet C, Rainey WE, Modani C, Chambaz EM. Type β transforming growth factor effects adrenocortical cell-differentiated functions. J Biol Chem 1987; 262: 13491-5
Rainey WE, Viard I, Mason JI, Cochet C, Chambaz EM, Saez JM. Effects of transforming growth factor beta on ovine adrenocortical cells. Mol Cell Endocrinol 1988; 60: 189-98
Ill CR, Gospodarowicz D. Factors involved in supporting the growth and steroidogenic functions of bovine adrenal cortical cells maintained on extracellular matrix and exposed to a serum-free medium. J Cell Physiol 1982; 113: 373-84
Natarajan R, Nadler J. Platelet-derived growth factor is a potent inhibitor of angiotensin II-induced aldosterone synthesis. Mol Cell Endocrinol 1992; 83: 57-63
Penhoat A, Chatelain PG, Jaillard C, Saez JM Characterization of insulin-like growth factor 1 and insulin receptors on cultured bovine adrenal fasciculata cells. Role of these peptides on adrenal cell function. Endocrinology 1988; 122: 2518-26
Cochet C, Feige JJ, Chambaz EM. Bovine adrenocortical cells exhibit high affinity transforming growth factor-β receptors which are regulated by adrenocorticotropin. J Biol Chem 1988; 263: 5707-13
Feige JJ, Cochet C, Savona C, Shi DL, Keramidas M, Defaye G, Chambaz EM. Transforming growth factor-β1 - An autocrine regulator of adrenocortical steroidogenesis. Endocrine Res 1991; 17: 267-79
Lebrethon MC, Jaillard C, Naville D, Bégeot M, Saez JM. Effects of transforming growth factor-β1 on human adrenocortical fasciculata-reticularis cell differentiated functions. J Clin Endocrinol Metab 1994; 79: 1033-9
Massague J, Weis-Garcia F. Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. In cancer Surveys Cell Signalling 1996; 27: 41-64
Penhoat A, Ouali R, Viard I, Langlois D, Saez JM. Regulation of primary response and specific genes in adrenal cells by peptide hormones and growth factors. Steroids 1996; 61: 176-83
Rainey WE, Viard I, Saez JM. Transforming growth factor beta treatment decreases ACTH receptors on ovine adrenocortical cells. J Biol Chem 1989; 264: 21474-7
Langlois D, Ouali R, Berthelon MC, Derrien A, Saez JM. Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of GQand g11 in bovine adrenal cells. Endocrinology 1994; 135: 480-3
Lebrethon MC, Ouali MC, Penhoat A, Naville D, Langlois D, Bégeot M, Saez JM. Characterization and regulation of corticotropin and angiotensin II receptors in human and bovine adrenal cells. In: Adrenal Glands, Vascular System and Hypertension. Vinson GP, Anderson DC, editors. Bristol: J Endocrinol. Ltd. 1996: 1-15
Lebrethon MC, Jaillard C, Naville D, Bégeot M, Saez JM. Regulation of corticotropin and steroidogenic enzyme mRNAs in human fetal adrenal cells by corticotropin, angiotensin-II and transforming growth factor β1. Mol Cell Endocrinol 1994; 106: 137-43
Perrin A, Pascal O, Defaye G, Feige JJ, Chambaz EM. Transforming growth factor β1 is a negative regulator of steroid 17 alpha-hydroxylase expression in bovine adrenocortical cells. Endocrinology 1990; 128: 357-62
Rainey WE, Naville D, Mason JI. Regulation of 3β-hydroxysteroid dehydrogenase in adrenocortical cells - Effects of angiotensin-II and transforming growth factor-β. Endocrine Res 1991; 17: 281-96
Rainey WE, Naville D, Saez JM, Carr BR, Byrd W, Magness RR, Mason JI. Transforming growth factor-β inhibits steroid 17-alpha-hydroxylase cytochrome-P-450 expression in ovine adrenocortical cells. Endocrinology 1990; 127: 1910-5
Naville D, Rainey WE, Mason JI. Corticotropin regulation of 3β-hydroxysteroid dehydrogenase/Δ-5-→ 4-Isomerase in ovine adrenocortical cells - Inhibition by transforming growth factor β. Mol Cell Endocrinol 1991; 75: 257-63
Rainey WE, Oka K, Magness RR, Mason JI. Ovine fetal adrenal synthesis of cortisol - Regulation by adrenocorticotropin, angiotensin-II and transforming growth factor-β. Endocrinology 1991; 129: 1784-90
Avallet O, Vigier M, Leduque P, Dubois PM, Saez JM. Expression and regulation of transforming growth factor-β1 messenger ribonucleic acid and protein in cultured porcine Leydig and Sertoli cells. Endocrinology 1994; 134: 2079-87
Keramidas M, Bourgarit JJ, Tabone E, Corticelli P, Chambaz EM, Feige JJ. Immunolocalization of transforming growth factor-β1 in the bovine adrenal cortex using antipeptide antibodies. Endocrinology 1991; 129: 517-26
Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 1988; 106: 1659-66
Bonewald LF, Wakefield L, Oreffo ROC, Escobedo A, Twardzik DR, Mundy GR. Latent forms of transforming growth factor-β (TGFβ) derived from bone cultures - Identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGFβ. Mol Endocrinol 1991; 5: 741-51
Bottinger EP, Factor VM, Tsang MLS, Weatherbee JA, Kopp JB, Qian SW, Wakefield LM, Roberts AB, Thorgeirsson SS, Sporn MB. The recombinant proregion of transforming growth factor ß1 (latency-associated peptide) inhibits active transforming growth factorβ1 in transgenic mice. Proc Natl Acad Sci USA 1996; 93: 5877-82
Le Roy C, Leduque P, Dubois PM, Saez JM, Langlois D. Repression of transforming growth factorβ1 protein by antisense oligonucleotide-induced increase of adrenal cell differentiated functions. J Biol Chem 1996; 271: 11027-33
Le Roy C, Leduque P, Saez JM, Li JY, Langlois D. Demonstration by an antisense approach that transforming growth factorβ1 plays an autocrine/paracrine inhibitory action on cultured Leydig cells differentiated functions. 79th Annual Meeting of the Endocrine Society. Minneapolis June 11-14, 1997, abstract P2341.