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| Reference : MMP-19 Deficiency Promotes Tenascin-C Accumulation and Allergen-induced Airway Inflammat... |
| Scientific journals : Article | |||
| Human health sciences : Rheumatology Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/1805 | |||
| MMP-19 Deficiency Promotes Tenascin-C Accumulation and Allergen-induced Airway Inflammation. | |
| English | |
Guéders, Maud  [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >] | |
| Hirst, S. [ > > ] | |
| Quesada Calvo, Florence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >] | |
| Paulissen, Geneviève [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >] | |
| Hacha, Jonathan [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >] | |
| Gilles, Christine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >] | |
| Gosset, P. [ > > ] | |
| Louis, Renaud [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie >] | |
| Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >] | |
| Lopez-Otin, C. [ > > ] | |
| Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >] | |
| Cataldo, Didier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >] | |
| 2010 | |
| American Journal of Respiratory Cell and Molecular Biology | |
| American Thoracic Society | |
| 43 | |
| 3 | |
| 286-95 | |
| Yes (verified by ORBi) | |
| International | |
| 1044-1549 | |
| 1535-4989 | |
| New York | |
| NY | |
| [en] eosinophils ; inflammation ; lung ; MMP-19 ; knockout mice. | |
| [en] Matrix metalloproteinases (MMPs) recently appeared as key regulators of inflammation,
allowing recruitment and clearance of inflammatory cells and modifying the biological activity of many peptidic mediators by cleavage. MMP-19 is a newly described MMP and preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date. The purpose of the present study was to assess MMP-19 expression in a murine asthma model and to address biological effects of MMP-19 deficiency in mice. Allergenexposed wild-type (WT) mice displayed an increased expression of MMP-19 mRNA and an increased number of MMP-19-positive cells in the lungs detected by immunohistochemistry. After allergen challenge of MMP-19 knockout (MMP-19-/-) mice, an exacerbated eosinophilic inflammation was detected in bronchoalveolar lavage fluid and bronchial tissue along with an increased airway responsiveness to methacholine. A shift towards increased Th2-driven inflammation in MMP-19-/- mice was demonstrated by 1) increased numbers of cells expressing the IL-33 receptor T1/ST2 in lung parenchyma, 2) increased IgG1 levels in serum and 3) higher levels of IL-13 and CCL11 in lung extracts. Tenascin-C was found accumulated in peribronchial areas of MMP-19-/- after allergen challenges as assessed by Western blot and immunohistochemistry analysis. We conclude that MMP-19 is a new mediator in asthma, preventing tenascin-C accumulation and directly or indirectly controlling Th2-driven airway eosinophilia and airway hyperreactivity. Our data suggest that MMP-19 might act on Th2 inflammation homeostasis through preventing tenascin protein accumulation. | |
| http://hdl.handle.net/2268/1805 |
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