Reference : Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by huma...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/18041
Natural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum
English
Machiels, Bénédicte mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Gillet, Laurent mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Brito, Sieberth Do Nascimento [> >]
Drion, Pierre mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
Delforge, Cédric mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Nizet, Yannick [Université Catholique de Louvain - UCL >]
Gianello, Pierre [Université Catholique de Louvain - UCL >]
Bona, Christophe [> >]
Costes, Bérénice [Université de Liège - ULg > > Immunologie et vaccinologie >]
Markine-Goriaynoff, Nicolas [> >]
Vanderplasschen, Alain mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
2007
Microbes & Infection
Elsevier Science
9
14-15
1530-1537
Yes (verified by ORBi)
International
1286-4579
Amsterdam
The Netherlands
[en] Bovine herpesvirus 4 ; Innate anti-viral immunity ; Virus neutralization ; Natural antibodies
[en] In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections. In the present study, we investigate the sensitivity of BoHV-4 to neutralization by naïve human sera in order to determine if humans exhibit innate anti-viral activities against this virus. Our results demonstrate that human sera from naïve individuals, in contrast to the sera of naïve subjects from various animal species, neutralize BoHV-4 efficiently. A series of complementary experiments were performed to unravel the mechanism(s) of this neutralization. The data obtained in this study demonstrates that human serum neutralizes BoHV-4 in a complement dependent manner activated by natural antibodies raised against the Galalpha1-3Galbeta1-4GlcNAc-R epitope expressed by bovine cells
Researchers ; Professionals
http://hdl.handle.net/2268/18041
also: http://hdl.handle.net/2268/29062
10.1016/j.micinf.2007.08.007
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VPN-4PJCYK0-2&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=1f7db6185dc6f13484b1d3019ea5ad3e

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Machiels_2007_Microbes-and-Infection.pdfPublisher postprint309.13 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.