Reference : Influence of the Ixodes ricinus tick blood-feeding on the antigen-specific antibody resp...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/18031
Influence of the Ixodes ricinus tick blood-feeding on the antigen-specific antibody response in vivo.
English
Menten-Dedoyart, Catherine mailto [Université de Liège - ULg > > GIGA-Research >]
Couvreur, B. [> > > >]
Thellin, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Drion, Pierre mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
Herry, M. [> > > >]
Jolois, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
2008
Vaccine
Elsevier Science
26
52
6956-64
Yes (verified by ORBi)
International
0264-410X
Amsterdam
The Netherlands
[en] Anesthetics/pharmacology ; Animals ; Antibody Formation/drug effects/physiology ; B-Lymphocytes/immunology ; Cattle ; Enzyme-Linked Immunosorbent Assay ; Feeding Behavior ; Female ; Flow Cytometry ; Immunoglobulin G/biosynthesis/genetics ; Immunoglobulin M/biosynthesis/genetics ; Immunohistochemistry ; Immunologic Factors/immunology ; Ixodes/immunology ; Lymph Nodes/pathology ; Lymphocyte Count ; Male ; Mice ; Mice, Inbred BALB C ; Salivary Glands/chemistry ; Serum Albumin, Bovine/immunology ; Spleen/pathology ; T-Lymphocytes/immunology ; Tick Infestations/immunology/pathology
[en] The blood meal of hard ticks such as Ixodes ricinus lasts several days. This is made possible by tick salivary factors that inhibit inflammation, haemostasis and the host immune response. We assessed the latter on a model of immune response in vivo. A significant reduction of specific IgM and IgG levels was observed in BALB/c mice infested 5 days before injection with bovine serum albumin (BSA) and QuilA but not in mice infested 5 days after the immunization. This effect was not observed in mock-infested mice and could not be attributed to the use of anesthetics. The antibody response was not merely delayed and the Th(1)/Th(2) balance appeared not altered. T-dependent zones and germinal centers in lymph nodes draining the tick bite site showed no apparent morphological alterations or shift in T cell subpopulations. However, the spleens of tick-infested mice had also an enlarged red pulp, indicating an increased extramedullary haematopoietic activity.
Researchers ; Professionals
http://hdl.handle.net/2268/18031
10.1016/j.vaccine.2008.09.072

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