Article (Scientific journals)
Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.
Conteduca, Giuseppina
2014In Clinical and Experimental Medicine, 14 (1), p. 91-7
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Keywords :
FOXP3; Treg; Alopecia Areata
Abstract :
[en] Alopecia areata (AA), an autoimmune disease affecting anagen stage hair follicles, is associated with polymorphisms in immune-related genes and with decreased number of CD4+ CD25+ T regulatory cells (Treg). Treg function is modulated by the forkhead box protein 3 (FOXP3) transcription factor and by inducible costimulator (ICOS), through interaction with the relative ligand, ICOSLG, whose genes are polymorphic. The aim of the study was to investigate whether specific single nucleotide polymorphisms (SNPs) of the rs2294020 FOXP3 and/or rs378299 ICOSLG genes may be associated with AA. A case-control study was performed in 120 AA patients and 84 controls. SNPs were analyzed by gene sequencing. FOXP3 and ICOSLG gene expressions were analyzed by real-time PCR. Increased frequencies of the genotype carrying the FOXP3 rs2294020-3675(A) [P = 0.002, OR (95 % CI): 2.55 (1.2-2.7)] or the ICOSLG rs378299-509(C) [P = 0.01, OR (95 % CI): 2.21 (1.1-2.6)] allelic variants were observed in AA patients than in controls. The genotype carrying the combination of the FOXP3 rs2294020-3675(A) and ICOSLG rs378299-509(C) allelic variants with the HLA DQB1*03 allele was more frequently present in AA patients than in controls (P = 0.04). The presence of the FOXP3 rs2294020-3675(A) or the ICOSLG rs378299-509(C) allelic variant was associated with reduced relative gene expression in AA patients. These data suggest that rs2294020 SNP of FOXP3 gene and rs378299 SNP of ICOSLG gene are associated with AA and with a reduced expression of the FOXP3 and ICOSLG genes in alopecia patients.
Research center :
Centre of Excelence for Biomedical Research
Disciplines :
Genetics & genetic processes
Author, co-author :
Conteduca, Giuseppina ;  Université de Liège - ULiège > GIGA-R : Hématologie
Language :
English
Title :
Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.
Publication date :
February 2014
Journal title :
Clinical and Experimental Medicine
ISSN :
1591-8890
eISSN :
1591-9528
Publisher :
Springer Science & Business Media B.V.
Volume :
14
Issue :
1
Pages :
91-7
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Genetic analysis in patients with Alopecia Areata
Funders :
Associazione Italiana Alopecia Areata
Available on ORBi :
since 27 March 2015

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