Short communication (Scientific journals)
KDIGO Guidelines and Kidney Transplantation: Is the cystatin-C Based Recommendation relevant?
Masson, I; Maillard, N; CAVALIER, Etienne et al.
2015In American Journal of Transplantation, 15 (8), p. 2211-4
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Abstract :
[en] The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1.73m2 as estimated by the CKD-EPI creatinine equation (eGFRcreat), it is suggested to con®rm the diagnosis with a second estimation using the CKD-EPI cystatin C-based equations (eGFRcys/eGFRcreat-cys). We sought to determine whether this new diagnostic strategy might extend to kidney transplant recipients (KTR) and help to identify those with decreased GFR. In 670 KTR for whom a measured GFR was available, we simulated the detection of CKD using the two-steps approach recommended by the guidelines in comparison to the conventional approach relying on creatinine equation. One hundred forty-®ve patients with no albuminuria had eGFRcreat between 45 and 59 mL/ min/1.73m2. Among them, 23% had inulin clearance over 60 mL/min/1.73m2 and were thus incorrectly classi®ed as CKD patients. When applying the Kidney Disease: Improving Global Outcomes (KDIGO) strategy, 138 patients were con®rmed as having a GFR below 60 mL/min with eGFRcreat-cys. However, 21% of them were misclassi®ed in reference to measured GFR. Our data do no not support the use of cystatin C as a con®rmatory test of stage 3A CKD in KTR.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Masson, I
Maillard, N
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Alamartine, E
Mariat, C
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Language :
English
Title :
KDIGO Guidelines and Kidney Transplantation: Is the cystatin-C Based Recommendation relevant?
Publication date :
2015
Journal title :
American Journal of Transplantation
ISSN :
1600-6135
eISSN :
1600-6143
Publisher :
Blackwell Publishing
Volume :
15
Issue :
8
Pages :
2211-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 March 2015

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