Article (Scientific journals)
Novel nanosized water soluble fluorescent micelles with embedded perylene diimide fluorophores for potential biomedical applications: Cell permeability, localization and cytotoxicity
Bryaskova, Rayna; Georgiev, Nikolai I.; Dimov, Stefan M. et al.
2015In Materials Science and Engineering: C: Materials for Biological Applications, 51, p. 7-15
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Keywords :
biomaterial; nanomedicine
Abstract :
[en] Novel biocompatiblewater-soluble fluorescent micelleswithembedded perylene diimides (PDI) for intracellular applications have been prepared by self assembling of amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVA-b-PAN) copolymers in the presence of synthesized fluorophores. Amphiphilic PVA-b-PAN copolymers were obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) copolymer. The preparation of the novel fluorescence micelles consisting of PVA hydrophilic shell and PAN hy- drophobic core with incorporated PDI fluorophores has been confirmed by DLS and TEManalysis. The cytotoxic- ity of the water-soluble fluorophores and their internalization into living cells depending on the micellar concentration have been tested. Itwas shown that they could successfully enter in living cellswithout destroying their morphology. The results obtained indicate that the novel water-soluble fluorescent micelles with embed- ded PDI fluorophores would be suitable for potential intracellular biomedical applications.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Bryaskova, Rayna;  University of Chemical Technology and Metallurgy, Sofia, Bulgaria, Department of Polymer Engineering
Georgiev, Nikolai I.;  University of Chemical Technology and Metallurgy, Sofia, Bulgaria, Department of Organic Synthesis
Dimov, Stefan M.;  University of Chemical Technology and Metallurgy, Sofia, Bulgaria, Department of Organic Synthesis
Tzoneva, Rumiana;  Bulgarian Academy of Science, Sofia, Bulgaria, Institute of Biophysics and Biomedical Engineering
Detrembleur, Christophe ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Asiri, Abdullah M.;  King Abdulaziz University, Jeddah, Saudi Arabia, Chemistry Department, Faculty of Sciences and Center of Excellence for Advanced Materials Research (CEAMR)
Alamry, Khalid A.;  King Abdulaziz University, Jeddah, Saudi Arabia, Chemistry Department, Faculty of Sciences
Bojinov, Vladimir B.;  University of Chemical Technology and Metallurgy, Sofia, Bulgaria, Department of Organic Synthesis > King Abdulaziz University, Jeddah, Saudi Arabia, Chemistry Department, Faculty of Sciences
Language :
English
Title :
Novel nanosized water soluble fluorescent micelles with embedded perylene diimide fluorophores for potential biomedical applications: Cell permeability, localization and cytotoxicity
Publication date :
01 June 2015
Journal title :
Materials Science and Engineering: C: Materials for Biological Applications
ISSN :
0928-4931
eISSN :
1873-0191
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
51
Pages :
7-15
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BNSF - Bulgarian National Science Fund [BG]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 17 March 2015

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