Article (Scientific journals)
Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves; Yemoa, Achille et al.
2015In Journal of Pharmaceutical and Biomedical Analysis, 111, p. 21-27
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Keywords :
Substandard drugs; counterfeit drugs; NIR spectroscopy; Raman Spectroscopy; Accuracy profiles
Abstract :
[en] Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Mbinze Kidenge, Jérémie 
Sacre, Pierre-Yves   ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Yemoa, Achille
Mavar Tayey Mbay, Jean
Habyalimana, Védaste
Kalenda, Nick
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Ziemons, Eric  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
 These authors have contributed equally to this work.
Language :
English
Title :
Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Publication date :
10 July 2015
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
111
Pages :
21-27
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
CUD - Commission Universitaire pour le Développement [BE]
Available on ORBi :
since 10 March 2015

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