Article (Scientific journals)
Evaluation of a class of polyurethane materials for intraocular lens manufacturing.
Bozukova, Dimitriya; Bertrand, Virginie; Pagnoulle, Christophe et al.
2014In Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Peer Reviewed verified by ORBi
 

Files


Full Text
Bozukova_et_al-2014-Journal_of_Biomedical_Materials_Research_Part_B__Applied_Biomaterials.pdf
Publisher postprint (758.55 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
biocompatibility; biomaterials; intraocular lens; polyurethanes; thermoplastic elastomers
Abstract :
[en] Ophthalmic lenses are medical devices with considerable requirements in terms of optical, biomechanical and biological performance. There is limited number of materials used for their manufacturing, comprising mainly silicones and poly(meth)acrylates. This series of publications aims at investigating the applicability of thermoplastic polyurethane elastomers (TPU) for the manufacturing of ophthalmic lenses and examining the properties of the respective devices. This study is related to the synthesis of TPUs with chemical compositions that comprise chemically grafted filters for the hazardous-light. GC-MS, attenuated total reflectance Fourier transform infrared spectroscopy, and UV-vis spectroscopies confirmed the reaction completion and the beneficial effect of the filters on the light transmittance, respectively. Relatively high refractive index of the material was measured and allows for the manufacturing of thinner lenses. The contrast sensitivity determined for a model intraocular lens (IOL) was satisfactory. Few optical defects were, however, present on the model lens prepared by thermoplastic injection molding. The elasticity of the materials was evaluated in view to their potential applicability as foldable IOLs by determining their glass transition temperature and their Young modulus and measuring their shore A. The TPU materials demonstrated more bioadhesive character compared with a benchmark hydrophilic acrylic reference material, which is already used for IOL manufacturing. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2014.
Research center :
Giga-Systems Biology and Chemical Biology - ULiège
Disciplines :
Ophthalmology
Author, co-author :
Bozukova, Dimitriya
Bertrand, Virginie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Pagnoulle, Christophe
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Evaluation of a class of polyurethane materials for intraocular lens manufacturing.
Publication date :
29 October 2014
Journal title :
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
ISSN :
1552-4973
eISSN :
1552-4981
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 Wiley Periodicals, Inc.
Available on ORBi :
since 26 February 2015

Statistics


Number of views
55 (3 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
11
Scopus citations®
without self-citations
11
OpenCitations
 
11

Bibliography


Similar publications



Contact ORBi