Article (Scientific journals)
Ustekinumab and Herpes Zoster
FAILLA, Valérie; NIKKELS, Arjen
2010In Dermatology
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Keywords :
Biologics; Anti-IL-12/23; Anti-p40; varicella zoster virus; Herpes zoster
Abstract :
[en] Background: TNF-alpha antagonists may increase the risk of herpes zoster (HZ), as well as the duration and severity. Recently, the monoclonal antibody ustekinumab, blocking the p40 subunit of IL-12 and IL-23, has been introduced for treating moderate to severe plaque psoriasis. There are no PubMed reports of HZ occurring in people receiving ustekinumab treatment. Common HZ was reported in clinical trials. Observation: Two patients with severe psoriasis treated with ustekinumab developped severe contiguous multidermatomal HZ 1 and 9 months after treatment initiation. Discussion : The occurence of HZ after the instauration of ustekinumab suggests a causal relationship. Indeed, the inhibition of the p40 subunit of IL-12 shifts the immune response towards a Th1 profile with diminished IFN-gamma and TNF-alpha expression, decreasing the antiviral immune reponse. Conclusion : Ustekinumab is probably a risk factor for developing HZ. Anti-HZ vaccination prior to ustekinumab treatment should be considered.
Disciplines :
Dermatology
Author, co-author :
FAILLA, Valérie ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Language :
English
Title :
Ustekinumab and Herpes Zoster
Publication date :
2010
Journal title :
Dermatology
ISSN :
1018-8665
eISSN :
1421-9832
Publisher :
S. Karger, Basel, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 February 2015

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