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Poster (Scientific congresses and symposiums)
The Expression of the Pituitary Growth Hormone Receptors by Blood Mononuclear Cells Can Be Modulated
Coumans, Bernard; Thellin, Olivier; Zorzi, Willy et al.
1997First Conference on Hormones, Blood Cells and Immunity
 

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Keywords :
Placental growth hormone; Pituitary growth hormone; Choriocarcinoma cell lines; Lymphoblastic cell lines; Cell proliferation; Flow cytometry
Abstract :
[en] The action of the human pituitary growth hormone has been recently revealed in addition to its traditionnal effects on the staturo-ponderal growth and on the lipid and carbohydrate metabolism. We demonstrated the presence of hGH-N receptors by cytometry in various peripheral mononuclear blood cells. These hGH-N-R were detected on B lymphocytes and on monocytes, contrarily to the T cells which were mostly negative. Since most blood cells are in a quiescent state, we have tested hGH-N-R expression by stimulated cultured blood cells. After PHA-L activation, most of T cells did express hGH-N-R. After SAC stimulation, B cells continue to express hGH-N-R. Monocytes can be induced to enhance the hGH-N-R expression. Since lymphocyte activation requires antigen recognition and costimulatory signals given by accessory or lymphoid cells, we can now hypothesise that activated cells bear higher numbers of certain receptors rendering them particularly receptive to messages, such as growth hormone, from the neuro-endocrine system. Quiescent B cells appear more sensitive to growth hormone signalling than T cells, but activation open the latter to the influence of growth hormone. The sensitivity of the immune system to signals of the neuro-endocrine system thus depends on its stimulation level. These observations reinforce the view that hGH-N is part of the immune system regulation machinery.
Research center :
Service d'Histologie humaine
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Coumans, Bernard ;  Université de Liège - ULiège > GIGA - Neurosciences
Thellin, Olivier ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie
Zorzi, Willy ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie
Igout, Ahmed ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
The Expression of the Pituitary Growth Hormone Receptors by Blood Mononuclear Cells Can Be Modulated
Publication date :
1997
Event name :
First Conference on Hormones, Blood Cells and Immunity
Event place :
Obernai, France
Event date :
Du 3 octobre 1997 au 8 octobre 1997
Audience :
International
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Région wallonne [BE]
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since 29 January 2015

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