Reference : Synthesis of poly(vinyl alcohol)/C60 and poly(N-vinylpyrrolidone)/C60 nanohybrids as po...
Scientific journals : Article
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/17746
Synthesis of poly(vinyl alcohol)/C60 and poly(N-vinylpyrrolidone)/C60 nanohybrids as potential photodynamic cancer therapy agents
English
Hurtgen, Marie [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Debuigne, Antoine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Mouithys-Mickalad, Ange mailto [University of Liège (ULg) > > Center for Oxygen Research and Development (CORD) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
1-Apr-2010
Chemistry : An Asian Journal
5
4
859-868
Yes
International
1861-4728
1861-471X
[en] radical polymerization ; cobalt-mediated radical polymerization (CMRP) ; biomaterial ; nanomedicine
[en] Well-defined poly(vinyl acetate) (PVAc) and poly(N-vinylpyrrolidone)-co-poly(vinyl acetate) (PNVPco-PVAc) chains end-capped by Co-(acac)2 (acac=acetylacetonate) and prepared by cobalt-mediated radical polymerization (CMRP) are grafted onto a fullerene. Homolytic Co-C bond cleavage of the polymer chain ends at 30°C releases the polymeric radicals that add onto C60, thereby leading to the corresponding PVAc/C60 and PNVP-co-PVAc/C60 nanohybrids. The [polymer–Co(acac)2]/[C60] molar ratio was varied to adjust the structure of the nanohybrids, and more particularly the number of grafted arms. Finally, the potential of the hydrosoluble PVOH/C60 nanohybrids, which result from the methanolysis of the ester groups of PVAc/C60, and of the PNVP-co-PVAc/C60 nanohybrids as photosensitizers for photodynamic therapy (PDT), was approached. First, photobleaching tests demonstrated the ability of these nanohybrids to produce singlet oxygen upon irradiation, which can play a role in cell damage. Second, cell viability assays demonstrated that both types of nanohybrids are deprived of intrinsic cytotoxicity in the dark, whereas they promoted significant cell mortality when subjected to light treatment. The selective response of these materials to irradiation makes them promising compounds for PDT.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/17746
10.1002/asia.200900277
http://www3.interscience.wiley.com/cgi-bin/fulltext/123275397/PDFSTART
http://www3.interscience.wiley.com/journal/123275397/suppinfo

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