Poster (Scientific congresses and symposiums)
Schistosoma mansoni egg-induced inflammation inhibits γ-herpesvirus replication
Dougall, Annette; Rolot, Marion; Vanderplasschen, Alain et al.
2014cell-symposia: the multifaceted roles of the immunity
 

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Abstract :
[en] Geographically, S. mansoni overlaps with human γ-herpesvirus infections such as Kaposi’s sarcoma-associated herpesvirus. The strongly regulated Th2-type immune response generated during infection by S. mansoni may jeopardize or improve the host’s ability to generate effective immunity against co-infecting pathogens, such as viruses. Here, we have trialled two approaches using murine herpesvirus-4 (MuHV-4). The first used a S. mansoni egg model to induce lung granulomas followed by intranasal infection with the MuHV-4-luc+ recombinant virus. Alternatively, we naturally infected mice with S. mansoni cercariae to induce a systemic Th2-type response and granulomas in the liver and intestine before intranasal MuHV-4-luc+ infection. We observed in both models a significant reduction of MuHV-4 replication in the lungs at day 5 and 7 pi associated with reduced weight loss caused by MuHV-4 infection. These results indicate that helminth induce Th2-type responses could inhibit and protect against viral infection.
Disciplines :
Immunology & infectious disease
Author, co-author :
Dougall, Annette ;  Université de Liège - ULiège > Immunologie et vaccinologie
Rolot, Marion ;  Université de Liège - ULiège > Immunologie et vaccinologie
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
Schistosoma mansoni egg-induced inflammation inhibits γ-herpesvirus replication
Publication date :
December 2014
Event name :
cell-symposia: the multifaceted roles of the immunity
Event date :
10-12 december 2014
Available on ORBi :
since 21 January 2015

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