Article (Scientific journals)
Place de la vitamine D native en dialyse
DELANAYE, Pierre; BOUQUEGNEAU, Antoine; KRZESINSKI, Jean-Marie et al.
2015In Néphrologie et Thérapeutique, 11 (1), p. 5-15
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Keywords :
Cholecalciferol; ergocalciferol; dialysis
Abstract :
[en] Chronic kidney disease is frequent and usually responsible of mineral and bone disorder. These abnormalities lead to increased morbidity and mortality. To become active, native vitamin D needs a first hydroxylation in the liver, and a second one in the kidney. Next to its action on bone metabolism, vitamin D also possesses pleiotropic actions on cardiovascular, immune and neurological systems as well as antineoplastic activities. End-stage renal disease (ESRD) is also associated with a decrease in vitamin D activity by mechanisms including the increase of plasma phosphate concentration, secretion of FGF- 23 and decrease in 1a-hydroxylase activity. The prevalence of 25 hydroxy-vitamin D deficiency depends on the chosen cut-off value to define this lack. Currently it is well established that a patient has to be substituted when 25 hydroxy-vitamin D level is under 30 ng/mL. The use and monitoring of 1.25 hydroxy-vitamin D is still not recommended in routine practice. The goals of vitamin D treatment in case of ESRD are to substitute the deficiency and to prevent or treat hyperparathyroidism. Interest of native vitamin D in first intention is now well demonstrated. This review article describes the vitamin D metabolism and physiology and also the treatment for vitamin D deficiency in ESRD population.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
BOUQUEGNEAU, Antoine  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
KRZESINSKI, Jean-Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Jean, Guillaume
Urena-Torres, Pablo
Souberbielle, Jean-Claude
Language :
French
Title :
Place de la vitamine D native en dialyse
Alternative titles :
[en] Native vitamin D in dialysis patients
Publication date :
February 2015
Journal title :
Néphrologie et Thérapeutique
ISSN :
1769-7255
eISSN :
1872-9177
Publisher :
Elsevier, Paris, France
Volume :
11
Issue :
1
Pages :
5-15
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 January 2015

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