Article (Scientific journals)
Purinergic control of inflammation and thrombosis: Role of P2X1 receptors
Oury, Cécile; LECUT, Christelle; Hego, Alexandre et al.
2015In Computational and Structural Biotechnology Journal, 13, p. 106-110
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Keywords :
thrombosis; inflammation; P2X receptors
Abstract :
[en] Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between inflammation and thrombosis. On platelets, P2X1 receptors act to amplify platelet activation and aggregation induced by other platelet agonists. These receptors critically contribute to thrombus stability in small arteries. Besides platelets, studies by our group indicate that these receptors are expressed by neutrophils. They promote neutrophil chemotaxis, both in vitro and in vivo. In a laser-induced injury mouse model of thrombosis, it appears that neutrophils are required to initiate thrombus formation and coagulation activation on inflamed arteriolar endothelia. In thismodel, by using P2X1−/−mice,we recently showed that P2X1 receptors, expressed on platelets and neutrophils, play a key role in thrombus growth and fibrin generation. Intriguingly, in a model of endotoxemia, P2X1−/−mice exhibited aggravated oxidative tissue damage, along with exacerbated thrombocytopenia and increased activation of coagulation, which translated into higher susceptibility to septic shock. Thus, besides its ability to recruit neutrophils and platelets on inflamed endothelia, the P2X1 receptor also contributes to limit the activation of circulating neutrophils under systemic inflammatory conditions. Taken together, these data suggest that P2X1 receptors are involved in the interplay between platelets, neutrophils and thrombosis. We propose that activation of these receptors by ATP on neutrophils and platelets represents a new mechanism that regulates thrombo-inflammation.
Disciplines :
Hematology
Author, co-author :
Oury, Cécile  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
LECUT, Christelle ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Hego, Alexandre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Wéra, Odile ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Delierneux, Céline ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Language :
English
Title :
Purinergic control of inflammation and thrombosis: Role of P2X1 receptors
Publication date :
16 January 2015
Journal title :
Computational and Structural Biotechnology Journal
eISSN :
2001-0370
Publisher :
elsevier
Volume :
13
Pages :
106-110
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 January 2015

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