[en] Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit for long-term asthma control outweighs the short-term risk of deterioration and hospitalisation in the days following the treatment. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based therapy, the overall evaluation of risk-benefit is unlike that of pharmaceutical products; safety aspects, regulatory requirements, study design and effect size assessment may be unfamiliar. The mechanisms of action and optimal patient selection need to be addressed in further rigorous clinical and scientific studies. Bronchial thermoplasty fits in perfectly with the movement to expand personalised medicine in the field of chronic airway disorders. This is a device-based complimentary asthma treatment that must be supported and developed in order to meet the unmet needs of modern severe asthma management. The mechanisms of action and the type of patients that benefit from bronchial thermoplasty are the most important challenges for bronchial thermoplasty in the future.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Dombret, Marie-Christine
Alagha, Khuder
Philippe Boulet, Louis
Yves Brillet, Pierre
Joos, Guy
Laviolette, Michel
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Rochat, Thierry
Soccal, Paola
Aubier, Michel
Chanez, Pascal
Language :
English
Title :
Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults.
Publication date :
December 2014
Journal title :
European Respiratory Review
ISSN :
0905-9180
eISSN :
1600-0617
Publisher :
European Respiratory Society, Sheffield, United Kingdom
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