Article (Scientific journals)
Whole-body MRI (WB-MRI) versus axial skeleton MRI (AS-MRI) to detect and measure bone metastases in prostate cancer (PCa)
Lecouvet, F. E.; Simon, M.; Tombal, B. et al.
2010In European Radiology, 20 (12), p. 2973-82
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Keywords :
Aged; Aged, 80 and over; Bone Neoplasms/ diagnosis/ secondary; Bone and Bones/ pathology; Humans; Magnetic Resonance Imaging/ methods; Male; Middle Aged; Prostatic Neoplasms/ diagnosis; Reproducibility of Results; Sensitivity and Specificity; Whole Body Imaging/ methods
Abstract :
[en] OBJECTIVE: To compare whole-body MRI (WB-MRI) and axial skeleton MRI (AS-MRI) in detecting and measuring bone metastases in patients with prostate cancer (PCa). METHODS: WB-MRI and AS-MRI examinations were performed in 60 patients with PCa at high risk of metastases. Two radiologists separately categorised the AS-MRI and WB-MRI as negative or positive for metastases, and measured focal metastases using the "Response evaluation criteria in solid tumours" (RECIST) criteria transposed to bone. One radiologist reviewed all examinations 2 months later. Inter- and intraobserver agreements in establishing the presence/absence of metastases were calculated. Bland-Altman plots were used to assess measurement agreement between AS-MRI and WB-MRI. RESULTS: Strong to perfect inter- and intraobserver agreements were found between AS-MRI and WB-MRI in defining the presence/absence of bone metastases. There were no patients with isolated "peripheral" metastases at WB-MRI, missed at AS-MRI. There was no difference in lesion count between the two radiologists. AS-MRI and WB-MRI provided statistically equivalent RECIST values for one radiologist and slightly lower values at AS-MRI for the other. CONCLUSIONS: In our series of PCa patients, AS-MRI and WB-MRI were equivalent in determining the presence/absence of bone metastases and provided similar evaluation of the metastatic burden.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Lecouvet, F. E.
Simon, M.
Tombal, B.
Jamart, Jean-Sébastien ;  Université de Liège - ULiège > Département de droit > Département de droit
Vande Berg, B. C.
SIMONI, Paolo ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Language :
English
Title :
Whole-body MRI (WB-MRI) versus axial skeleton MRI (AS-MRI) to detect and measure bone metastases in prostate cancer (PCa)
Publication date :
27 July 2010
Journal title :
European Radiology
ISSN :
0938-7994
eISSN :
1432-1084
Publisher :
Springer Science & Business Media B.V., New York, United States - New York
Volume :
20
Issue :
12
Pages :
2973-82
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
2010/07/28
Available on ORBi :
since 16 January 2015

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