Ellerbrock TV, Chiasson MA, Bush TJ, Sun XW, Sawo D, Brudney K, Wright TC Jr. Incidence of cervical squamous intraepithelial lesions in HIV-infected women. JAMA 2000; 283:1031-7; PMID:10697063; http://dx.doi.org/10.1001/jama.283.8.1031
Nakamura T, Shima T, Saeki A, Hidaka T, Nakashima A, Takikawa O, Saito S. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. Cancer Sci 2007; 98:874-81; PMID:17433037; http://dx.doi.org/10.1111/j.1349-7006.2007.00470.x
Giannini SL, Hubert P, Doyen J, Boniver J, Delvenne P. Influence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepithelial lesions of the cervix. Int J Cancer 2002; 97:654-9; PMID:11807793; http:// dx.doi.org/10.1002/ijc.10084
Nakayama Y, Asagoe K, Yamauchi A, Yamamoto T, Shirafuji Y, Morizane S, Nakanishi G, Iwatsuki K. Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions. J Dermatol Sci 2011; 63:173-83; PMID:21715145; http://dx.doi.org/10.1016/j. jdermsci.2011.05.006
Gottfried E, Kreutz M, Mackensen A. Tumor-induced modulation of dendritic cell function. Cytokine Growth Factor Rev 2008; 19:65-77; PMID:18061513; http://dx.doi.org/10.1016/j.cytogfr.2007.10.008
Walsh NC, Alexander KA, Manning CA, Karmakar S, Wang JF, Weyand CM, Pettit AR, Gravallese EM. Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL. Genes Immun 2013; 14:336-45; PMID:23698708; http://dx. doi.org/10.1038/gene.2013.29
Armstrong AP, Miller RE, Jones JC, Zhang J, Keller ET, Dougall WC. RANKL acts directly on RANKexpressing prostate tumor cells and mediates migration and expression of tumor metastasis genes. Prostate 2008; 68:92-104; PMID:18008334; http://dx.doi.org/ 10.1002/pros.20678
Beristain AG, Narala SR, Di Grappa MA, Khokha R. Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. J Cell Sci 2012; 125:943-55; PMID:22421365
Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 2010; 468:103-7; PMID:20881963; http://dx. doi.org/10.1038/nature09495
Levidou G, Thymara I, Saetta AA, Papanastasiou P, Pavlopoulos P, Sakellariou S, Fragkou P, Patsouris E, Korkolopoulou P. TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinicopathological parameters and prognosis. Pathology 2013; 45:138-44; PMID:23277172; http:// dx.doi.org/10.1097/PAT.0b013e32835c9891
Owen S, Ye L, Sanders AJ, Mason MD, Jiang WG. Expression profile of receptor activator of nuclear-kappaB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in breast cancer. Anticancer Res 2013; 33:199-206; PMID:23267146
Herfs M, Hubert P, Delvenne P. Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation? Trends Mol Med 2009; 15:245-53; PMID:19457719; http:// dx.doi.org/10.1016/j.molmed.2009.04.002
Hurwitz AA, Watkins SK. Immune suppression in the tumor microenvironment: a role for dendritic cellmediated tolerization of T cells. Cancer Immunol Immunother 2012; 61:289-93; PMID:22237887; http://dx.doi.org/10.1007/s00262-011-1181-5
Shklovskaya E, O'Sullivan BJ, Ng LG, Roediger B, Thomas R, Weninger W, Fazekas de St Groth B. Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci USA 2011; 108:18049-54; PMID:22006331; http://dx.doi.org/10.1073/ pnas.1110076108
Loser K, Beissert S. Dendritic cells and T cells in the regulation of cutaneous immunity. Adv Dermatol 2007; 23:307-33; PMID:18159907; http://dx.doi.org/ 10.1016/j.yadr.2007.07.014
Bosnjak L, Miranda-Saksena M, Koelle DM, Boadle RA, Jones CA, Cunningham AL. Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells. J Immunol 2005; 174:2220-7; PMID:15699155; http://dx.doi.org/10.4049/jimmunol.174.4.2220
Bedoui S, Whitney PG, Waithman J, Eidsmo L, Wakim L, Caminschi I, Allan RS, Wojtasiak M, Shortman K, Carbone FR et al. Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 2009; 10:488-95; PMID:19349986; http://dx.doi.org/10.1038/ni.1724
Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 2012; 21:402-17; PMID:22439936; http://dx.doi.org/10.1016/j. ccr.2012.01.008
Harimoto H, Shimizu M, Nakagawa Y, Nakatsuka K, Wakabayashi A, Sakamoto C, Takahashi H. Inactivation of tumor-specific CD8(+) CTLs by tumor-infiltrating tolerogenic dendritic cells. Immunol Cell Biol 2013; 91:545-55; PMID:24018532; http://dx.doi.org/ 10.1038/icb.2013.38
Ng RL, Scott NM, Strickland DH, Gorman S, Grimbaldeston MA, Norval M, Waithman J, Hart PH. Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice. J Immunol 2013; 190:5471-84; PMID:23636055; http://dx. doi.org/10.4049/jimmunol.1202786
Adikari SB, Pettersson A, Soderstrom M, Huang YM, Link H. Interleukin-10-modulated immature dendritic cells control the proinflammatory environment in multiple sclerosis. Scand J Immunol 2004; 59:600-6; PMID:15182256; http://dx.doi.org/10.1111/j.1365-3083.2004.01453.x
Adurthi S, Mukherjee G, Krishnamurthy H, Sudhir K, Bafna UD, Umadevi K, Jayshree RS. Functional tumor infiltrating TH1 and TH2 effectors in large early-stage cervical cancer are suppressed by regulatory T cells. Int J Gynecol Cancer 2012; 22:1130-7; PMID:22872166; http://dx.doi.org/10.1097/IGC.0b013e318262aa53
Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 2006; 12:1372-9; PMID:17143276; http://dx.doi.org/10.1038/nm1518
Santini D, Vincenzi B, Adamo V, Addeo R, Fusco V, Russo A, Montemurro F, Roato I, Redana S, Lanzetta G et al. Cigarette smoking habit does not reduce the benefit from first line trastuzumab-based treatment in advanced breast cancer patients. Oncol Rep 2011; 25:1545-8; PMID:21455582; http://dx.doi.org/ 10.3892/or.2011.1235
Kanematsu M, Sato T, Takai H, Watanabe K, Ikeda K, Yamada Y. Prostaglandin E2 induces expression of receptor activator of nuclear factor-kappa B ligand/ osteoprotegrin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency. J Bone Miner Res 2000; 15:1321-9; PMID:10893680; http://dx.doi.org/10.1359/jbmr.2000.15.7.1321
Herfs M, Herman L, Hubert P, Minner F, Arafa M, Roncarati P, Henrotin Y, Boniver J, Delvenne P. High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. Cancer Immunol Immunother 2009; 58:603-14; PMID:18802697; http://dx.doi.org/ 10.1007/s00262-008-0584-4
Kukita A, Kukita T. Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis. Future Oncol 2013; 9:1609-22; PMID:24156322; http://dx.doi.org/10.2217/ fon.13.115
Tanos T, Sflomos G, Echeverria PC, Ayyanan A, Gutierrez M, Delaloye JF, Raffoul W, Fiche M, Dougall W, Schneider P et al. Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med 2013; 5:182ra55; PMID:23616122; http://dx. doi.org/10.1126/scitranslmed.3005654
Schramek D, Sigl V, Penninger JM. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab 2011; 22:188-94; PMID:21470874; http://dx.doi.org/ 10.1016/j.tem.2011.02.007
Remoue F, Jacobs N, Miot V, Boniver J, Delvenne P. High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix. Am J Obstet Gynecol 2003 189:1660-5; PMID:14710094; http://dx.doi.org/10.1016/S0002-9378(03)00852-4
Monsonego J, Magdelenat H, Catalan F, Coscas Y, Zerat L, Sastre X. Estrogen and progesterone receptors in cervical human papillomavirus related lesions. Int J cancer 1991; 48:533-9; PMID:1646176; http://dx.doi. org/10.1002/ijc.2910480410
Demoulin S, Herfs M, Delvenne P, Hubert P. Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms. J Leukoc Biol 2013; 93:343-52; PMID:23136258; http://dx.doi.org/ 10.1189/jlb.0812397
Schiano de Colella JM, Barbarat B, Sweet R, Gastaut JA, Olive D, Costello RT. Rank ligand stimulation induces a partial but functional maturation of human monocyte-derived dendritic cells. Eur Cytokine Netw 2008; 19:81-8; PMID:18632421; http://dx.doi.org/ 10.1684/ecn.2008.0125
Josien R, Wong BR, Li HL, Steinman RM, Choi Y. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells. J Immunol 1999; 162:2562-8; PMID:10072496
Williamson E, Bilsborough JM, Viney JL. Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction. J Immunol 2002; 169:3606-12; PMID:12244151; http://dx.doi.org/ 10.4049/jimmunol.169.7.3606
Poulin LF, Henri S, de Bovis B, Devilard E, Kissenpfennig A, Malissen B. The dermis contains langerinC dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 2007; 204:3119-31; PMID:18086861; http://dx.doi.org/ 10.1084/jem.20071724
Romani N, Clausen BE, Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010; 234:120-41; PMID:20193016; http://dx.doi.org/10.1111/j.0105-2896.2009.00886.x
Ramos RN, de Moraes CJ, Zelante B, Barbuto JA. What are the molecules involved in regulatory T-cells induction by dendritic cells in cancer? Clin Dev Immunol 2013; 2013:806025; PMID:23762097; http://dx. doi.org/10.1155/2013/806025
Blank C, Gajewski TF, Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother 2005; 54:307-14; PMID:15599732; http://dx. doi.org/10.1007/s00262-004-0593-x
Yang W, Song Y, Lu YL, Sun JZ, Wang HW. Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia. Immunology 2013; 139:513-22; PMID:23521696; http://dx.doi.org/10.1111/ imm.12101
Karim R, Jordanova ES, Piersma SJ, Kenter GG, Chen L, Boer JM, Melief CJ, van der Burg SH. Tumorexpressed B7-H1 and B7-DC in relation to PD-1C Tcell infiltration and survival of patients with cervical carcinoma. Clin Cancer Res 2009; 15:6341-7; PMID:19825956; http://dx.doi.org/10.1158/1078-0432.CCR-09-1652
Manavalan JS, Rossi PC, Vlad G, Piazza F, Yarilina A, Cortesini R, Mancini D, Suciu-Foca N. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 2003; 11:245-58; PMID:12967778; http://dx.doi.org/10.1016/ S0966-3274(03)00058-3
Vlad G, Suciu-Foca N. Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3. Exp Mol Pathol 2012; 93:294-301; PMID:23018130; http://dx.doi.org/10.1016/j. yexmp.2012.09.011
Hamdi H, Godot V, Maillot MC, Prejean MV, Cohen N, Krzysiek R, Lemoine FM, Zou W, Emilie D. Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoidinduced leucine zipper. Blood 2007; 110:211-9; PMID:17356131; http://dx.doi.org/10.1182/blood-2006-10-052506
Cohen N, Mouly E, Hamdi H, Maillot MC, Pallardy M, Godot V, Capel F, Balian A, Naveau S, Galanaud P et al. GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response. Blood 2006; 107:2037-44; PMID:16293609; http://dx.doi.org/10.1182/blood-2005-07-2760
Li C, Zhao J, Sun L, Yao Z, Liu R, Huang J, Liu X. RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis. Biochem Biophys Res Commun 2012; 429:156-62; PMID:23142594; http://dx.doi.org/ 10.1016/j.bbrc.2012.10.122
Gur-Wahnon D, Borovsky Z, Liebergall M, Rachmilewitz J. The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation. PloS One 2009; 4:e6846; PMID:19718269; http://dx.doi.org/10.1371/journal.pone.0006846
Burkholder B, Huang RY, Burgess R, Luo S, Jones VS, Zhang W, Lv ZQ, Gao CY, Wang BL, Zhang YM et al. Tumor-induced perturbations of cytokines and immune cell networks. Biochim Biophys Acta 2014; 1845(2):182-201; PMID:24440852; http://dx.doi.org/ 10.1016/j.bbcan.2014.01.004
Anandkumar A, Devaraj H. Tumour immunomodulation: mucins in resistance to initiation and maturation of immune response against tumours. Scand J Immunol 2013; 78:1-7; PMID:23298229; http://dx.doi.org/ 10.1111/sji.12019
Luo JL, TanW, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokineactivated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 2007; 446:690-4; PMID:17377533; http://dx.doi.org/10.1038/ nature05656
Odero-Marah VA, Wang R, Chu G, Zayzafoon M, Xu J, Shi C, Marshall FF, Zhau HE, Chung LW. Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res 2008; 18:858-70; PMID:18645583; http://dx.doi.org/10.1038/ cr.2008.84
Kim JK, Jin X, Sohn YW, Jin X, Jeon HY, Kim EJ, Ham SW, Jeon HM, Chang SY, Oh SY et al. Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling. Cancer Lett 2014; 353:194-200; PMID:25079688; http://dx.doi.org/ 10.1016/j.canlet.2014.07.034
Buckle CH, De Leenheer E, Lawson MA, Yong K, Rabin N, Perry M, Vanderkerken K, Croucher PI. Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. PloS One 2012; 7:e41127; PMID:22952578; http://dx.doi.org/ 10.1371/journal.pone.0041127
Castellano D, Sepulveda JM, Garcia-Escobar I, Rodriguez-Antolin A, Sundlov A, Cortes-Funes H. The role of RANK-ligand inhibition in cancer: the story of denosumab. Oncologist 2011; 16:136-45; PMID:21285392; http://dx.doi.org/10.1634/ theoncologist.2010-0154
Herman L, Hubert P, Herfs M, Kustermans G, Henrotin Y, Bousarghin L, Boniver J, Delvenne P. The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context. Eur J Immunol 2010; 40:3075-84; PMID:21061438; http://dx.doi.org/ 10.1002/eji.201040571
Demoulin S, Roncarati P, Delvenne P, Hubert P. Production of large numbers of plasmacytoid dendritic cells with functional activities from CD34(+) hematopoietic progenitor cells: use of interleukin-3. Exp Hematol 2012; 40:268-78; PMID:22245566; http://dx.doi. org/10.1016/j.exphem.2012.01.002
Hubert P, Van Den Brule F, Giannini SL, Franzen-Detrooz E, Boniver J, Delvenne P. Colonization of in vitro-formed cervical human papillomavirus-associated (pre)neoplastic lesions with dendritic cells. Role of granulocyte/macrophage colony-stimulating factor. Am J Pathol 1999; 154:775-84; PMID:10079255; http:// dx.doi.org/10.1016/S0002-9440(10)65324-2
Hubert P, Greimers R, Franzen-Detrooz E, Doyen J, Delanaye P, Boniver J, Delvenne P. In vitro propagated dendritic cells from patients with human-papilloma virus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand. Cancer Immunol Immunother 1998; 47:81-9; PMID:9769116; http://dx.doi.org/ 10.1007/s002620050507
Caberg JH, Hubert P, Herman L, Herfs M, Roncarati P, Boniver J, Delvenne P. Increased migration of Langerhans cells in response to HPV16 E6 and E7 oncogene silencing: role of CCL20. Cancer Immunol Immunother 2009; 58:39-47; PMID:18438663; http://dx.doi.org/10.1007/s00262-008-0522-5
