Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia.

Juvenal Hajingabo, Leon; Daakour, Sarah; Martin, Maud; Grausenburger, Reinhard; Panzer-Grumayer, Renate; Dequiedt, Franck; Simonis, Nicolas; Twizere, Jean-Claude

doi:10.1091/mbc.E14-06-1038

Article (Scientific journals)

Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia.

Juvenal Hajingabo, Leon; Daakour, Sarah; Martin, Maud et al.

2014 • In Molecular Biology of the Cell

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/175399

DOI
10.1091/mbc.E14-06-1038

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25273558

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Abstract :

[en] Genomic variations such as point mutations and gene fusions are directly or indirectly associated with human diseases. They are recognized as diagnostic, prognostic markers and therapeutic targets. However, predicting the functional impact of these genetic alterations beyond affected genes and their products is challenging because diseased phenotypes are likely dependent of complex molecular interaction networks. Using as models three different chromosomal translocations ETV6-RUNX1 (TEL-AML1), BCR-ABL1, and TCF3-PBX1 (E2A-PBX1), frequently found in precursor-B cell acute lymphoblastic leukemia (preB-ALL), we develop an approach to extract perturbed molecular interactions from gene expression changes. We show that the MYC and JunD transcriptional circuits are specifically deregulated following ETV6-RUNX1 and TCF3-PBX1 gene fusions, respectively. We also identified the bulk mRNA NXF1-dependent machinery as a direct target for the TCF3-PBX1 fusion protein. Through a novel approach combining gene expression and interactome data analysis, we provide new insight into TCF3-PBX1 and ETV6-RUNX1 acute lymphoblastic leukemia.

Research center :

Protein Signaling and Interactions GIGA -Siganaling transduction

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Juvenal Hajingabo, Leon

Daakour, Sarah ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Martin, Maud ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Grausenburger, Reinhard

Panzer-Grumayer, Renate

Dequiedt, Franck ; Université de Liège - ULiège > GIGA-Research

Simonis, Nicolas

Twizere, Jean-Claude ; Université de Liège - ULiège > GIGA -Siganaling Transduction > Protein Signaling and Interactions > Principal Investigator

Language :

English

Title :

Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia.

Publication date :

2014

Journal title :

Molecular Biology of the Cell

ISSN :

1059-1524

eISSN :

1939-4586

Publisher :

American Society for Cell Biology, United States - Maryland

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

Perturbations of interactome network in acute lymphoblastic leukemia

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Commentary :

Available on ORBi :

since 20 December 2014

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