Article (Scientific journals)
Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO(2) ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: a research study part of the Biovisco study.
Henrotin, Yves; Chevalier, X.; DEBERG, Michelle et al.
2013In Journal of Orthopaedic Research, 31 (6), p. 901-7
Peer Reviewed verified by ORBi
 

Files


Full Text
Deberg 2013 Early decrease.pdf
Publisher postprint (688.35 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adult; Aged; Aged, 80 and over; Biological Markers/blood; Collagen Type II/blood; Female; Humans; Hyaluronic Acid/administration & dosage; Injections, Intra-Articular; Male; Middle Aged; Osteoarthritis, Knee/blood/drug therapy; Peptide Fragments/blood; Prospective Studies; Viscosupplements/administration & dosage
Abstract :
[en] To measure the evolution of the serum levels of specific Osteoarthritis (OA) biomarker, Coll2-1 and Coll2-1 NO(2) in knee osteoarthritic patients after viscosupplementation (VS). Fifty-one patients with unilateral symptomatic knee were recruited for this prospective open label study. They received three intra-articular injections of 2 ml of hyaluronic acid (Hylan GF-20) and were followed for 3 months. Walking pain was evaluated and serum samples were taken at each visit. Coll2-1 and Coll2-1 NO(2) were measured in the serum using specific immunoassays. Variations over time of each parameter and predictive factor of response were studied. Forty-five patients were analyzed. The serum concentrations of Coll2-1 and Coll2-1 NO(2) were significantly higher in KL III/IV patients compared to KL I/II patients at baseline and decreased systematically over time after VS. Its effect was ever more pronounced in patients with KL III/IV. The serum concentration of Coll2-1 was significantly lower at baseline in responders than in non-responders. This study suggests a rapid slowdown of type II collagen degradation and joint inflammation after VS with Hylan G-20 and gives additional information for the validation of accurate biomarkers for OA. The serum level of Coll2-1 appeared to be a predictive factor for response to treatment.
Disciplines :
Rheumatology
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Chevalier, X.
DEBERG, Michelle ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Balblanc, J. C.
Richette, P.
Mulleman, D.
Maillet, B.
Rannou, F.
Piroth, C.
Mathieu, Philippe ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Département d'aérospatiale et mécanique
Conrozier, T.
Language :
English
Title :
Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO(2) ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: a research study part of the Biovisco study.
Publication date :
2013
Journal title :
Journal of Orthopaedic Research
ISSN :
0736-0266
eISSN :
1554-527X
Publisher :
Wiley-Blackwell, Hoboken, United States - New Jersey
Volume :
31
Issue :
6
Pages :
901-7
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2013 Orthopaedic Research Society.
Available on ORBi :
since 17 December 2014

Statistics


Number of views
51 (3 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
51
Scopus citations®
without self-citations
34
OpenCitations
 
50

Bibliography


Similar publications



Contact ORBi