Article (Scientific journals)
Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants
Charlier, Corinne; Desaive, Claude; Plomteux, Guy
2002In International Journal of Obesity, 26 (11), p. 1465-1468
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Keywords :
gastroplasty; organochlorines; PCBs; obesity
Abstract :
[en] BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters). DESIGN: Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people. MEASUREMENTS: Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry. RESULTS: The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants. CONCLUSION: Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Charlier, Corinne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Desaive, Claude ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Plomteux, Guy ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants
Publication date :
November 2002
Journal title :
International Journal of Obesity
ISSN :
0307-0565
eISSN :
1476-5497
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
26
Issue :
11
Pages :
1465-1468
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 July 2009

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