Reference : Absence of Host Plasminogen Activator Inhibitor 1 Prevents Cancer Invasion and Vascul...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/17458
Absence of Host Plasminogen Activator Inhibitor 1 Prevents Cancer Invasion and Vascularization
English
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Gerard, R. D. [> > > >]
Masson, Véronique [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Brunner, N. [> > > >]
Holst-Hansen, C. [> > > >]
Skobe, M. [> > > >]
Fusenig, N. E. [> > > >]
Carmeliet, P. [> > > >]
Collen, D. [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Aug-1998
Nature Medicine
Nature Publishing Group
4
8
923-8
Yes (verified by ORBi)
International
1078-8956
1546-170X
New York
NY
[en] Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been correlated with a poor prognosis for some cancers. We report here that deficient PAI1 expression in host mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes. When this PAI1 deficiency was circumvented by intravenous injection of a replication-defective adenoviral vector expressing human PAI1, invasion and associated angiogenesis were restored. This experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis.
http://hdl.handle.net/2268/17458

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