Article (Scientific journals)
Discongruence of Mhc and cytochrome b phylogeographical patterns in Myodes glareolus (Rodentia: Cricetidae)
Malé, P.-J. G.; Martin, J.-F.; Galan, M. et al.
2012In Biological Journal of the Linnean Society, 105 (4), p. 881-899
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Keywords :
Balancing selection; Bank voles; Diversity; Immunogenetics; Molecular epidemiology; Puumala hantavirus; Zoonoses; Last Glacial; Europe; Clethrionomys glareolus; Cricetidae; Hantavirus; Muridae; Puumala virus; Rodentia
Abstract :
[en] In the present study, a phylogeographical approach was developed to analyse the influence of selection and history on a major histocompatibility complex (Mhc) class II gene polymorphism in European bank vole (Myodes glareolus) populations. We focused on exon 2 of the Dqa gene because it is highly variable in a large array of species and appears to evolve under pathogen-mediated selection in several rodent species. Using single-strand conformation polymorphism analysis and sequencing techniques, 17 Dqa-exon2 alleles, belonging to at least two different copies of Dqa gene, were detected over the distribution range of M.glareolus. Evidence of selection was found using molecular and population analyses. At the molecular level, we detected 13 codons evolving under positive selection pressures, most of them corresponding to regions coding for putative antigen binding sites of the protein. At the European level, we compared patterns of population structure for the Dqa-exon2 and cytochrome b (cyt b) gene. We did not detect any spatial genetic structure among M.glareolus populations for the Dqa-exon2. These results strongly differed from those obtained using the cyt b gene, which indicated a recent phylogeographical history closely linked to the last glacial events. Seven mitochondrial lineages have yet been described, which correspond to major glacial refugia. Altogether, our results revealed clear evidence of balancing selection acting on Dqa-exon2 and maintaining polymorphism over large geographical areas despite M.glareolus history. It is thus likely that Mhc phylogeographical variability could have been shaped by local adaptation to pathogens. © 2012 The Linnean Society of London.
Disciplines :
Zoology
Author, co-author :
Malé, P.-J. G.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France, Université de Toulouse, UPS, EDB (Laboratoire Evolution et Diversité Biologique), 118 route de Narbonne, F-31062 Toulouse, France, CNRS, EDB, Laboratoire Evolution et Diversité Biologique, F31062 Toulouse, France
Martin, J.-F.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
Galan, M.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
Deffontaine, V.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France, Unité de recherches zoogéographiques, University of Liège, Bât. B22, Boulevard du Rectorat, Sart Tilman, 4000 Liège, Belgium, University of Liège, GIGA-R, Unit of Animal Genomics, B34, Avenue de l'Hopîtal, 4000 Liège, Belgium
Bryja, J.;  Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Květná 8, 603 65 Brno, Czech Republic
Cosson, J.-F.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
Michaux, Johan  ;  Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues
Charbonnel, N.;  INRA, UMR CBGP, INRA/IRD/Cirad/Montpellier SupAgro, Campus international de Baillarguet, CS 30016, F-34988 Montferrier-sur-Lez Cedex, France
Language :
English
Title :
Discongruence of Mhc and cytochrome b phylogeographical patterns in Myodes glareolus (Rodentia: Cricetidae)
Publication date :
2012
Journal title :
Biological Journal of the Linnean Society
ISSN :
0024-4066
eISSN :
1095-8312
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
105
Issue :
4
Pages :
881-899
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 November 2014

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