Glioblastoma-Initiating Cells: Relationship with Neural Stem Cells and the Micro-Environment

[en] Glioblastoma multiforme (GBM, WHO grade IV) is the most common and lethal subtype of primary brain tumor with a median overall survival of 15 months from the time of diagnosis. The presence in GBM of a cancer population displaying neural stem cell (NSC) properties as well as tumor-initiating abilities and resistance to current therapies suggests that these glioblastoma-initiating cells (GICs) play a central role in tumor development and are closely related to NSCs. However, it is nowadays still unclear whether GICs derive from NSCs, neural progenitor cells or differentiated cells such as astrocytes or oligodendrocytes. On the other hand, NSCs are located in specific regions of the adult brain called neurogenic niches that have been shown to control critical stem cell properties, to nourish NSCs and to support their self-renewal. This “seed-and-soil” relationship has also been adapted to cancer stem cell research as GICs also require a specific micro-environment to maintain their “stem cell” properties. In this review, we will discuss the controversies surrounding the origin and the identification of GBM stem cells and highlight the micro-environment impact on their biology.

Disciplines :

Oncology

Author, co-author :

Goffart, Nicolas ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

KROONEN, Jérôme ; Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie

Language :

English

Title :

Glioblastoma-Initiating Cells: Relationship with Neural Stem Cells and the Micro-Environment

Publication date :

14 August 2013

Journal title :

Cancers

eISSN :

2072-6694

Publisher :

MDPI AG, Basel, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.mdpi.com/2072-6694/5/3/1049

Available on ORBi :

since 15 November 2014

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