Article (Scientific journals)
Poly( N-vinylcaprolactam): A thermoresponsive macromolecule with promising future in biomedical field
Liu, Ji; Debuigne, Antoine; Detrembleur, Christophe et al.
2014In Advanced Healthcare Materials, 3 (12), p. 1941-1968
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Keywords :
biomaterial; stimuli responsive polymer; review
Abstract :
[en] Poly( N -vinylcaprolactam) (PNVCL) is a thermoresponsive and biocompatible polymer that raises an increasing interest in the biomedical area, especially in drug delivery systems (DDS) that include micelles, hydrogels, and hybrid particles. The thermoresponsiveness of PNVCL, used alone or in combination with other stimuli- responsive polymers or particles (pH, magnetic fi eld, or chemicals), is often key in the loading and/or release process in these DDS. The renewed focus on this polymer, which is known for decades, is to a large extent due to recent progress in synthetic strategies. Especially, the advent of efficient controlled radical polymerization (CRP) methods for NVCL monomer gives now access to unprecedented well-defi ned NVCL-based copolymers with unique properties. This Review article addresses up-to-date synthetic aspects, biological features, and biomedical applications of the latest NVCL-containing systems.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Liu, Ji;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Debuigne, Antoine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Detrembleur, Christophe ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Poly( N-vinylcaprolactam): A thermoresponsive macromolecule with promising future in biomedical field
Publication date :
December 2014
Journal title :
Advanced Healthcare Materials
ISSN :
2192-2640
eISSN :
2192-2659
Publisher :
Wiley
Volume :
3
Issue :
12
Pages :
1941-1968
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The International Doctoral School "IDS-Funmat"
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