Reference : Combined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside mo...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/17343
Combined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates
English
Zervosen, Astrid mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Stein, Andreas [> > > >]
Adrian, Holger [> > > >]
Elling, Lothar [> > > >]
1996
Tetrahedron
Pergamon Press
52
7
2395-2404
Yes (verified by ORBi)
International
0040-4020
Oxford
United Kingdom
[en] nucleotide sugar ; enzymatic synthesis
[en] Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside monophosphates la-d by different kinases A. Further combination with recombinant dTDP-glucose 4,6-dehydratase D enabled us to synthesize
dUDP-6-deoxy-alpha-D-xylo-4-hexulose 5 from ld on a preparative scale. By using the repetitive batch technique the enzymatic syntheses of nucleotide (deoxy) sugars 3a-d, 5 could be realized on a 0.1 - 0.5 g scale.
http://hdl.handle.net/2268/17343
10.1016/0040-4020(95)01081-5

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