Article (Scientific journals)
Vascular calcification: from pathophysiology to biomarkers
EVRARD, Séverine; DELANAYE, Pierre; Kamel, S et al.
2015In Clinica Chimica Acta, 438, p. 401-14
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Keywords :
vascualar calcification; Fibroblast growth factor-23; Fetuin-A; Matrix Gla protein; Bone morphogenetic protein-2; Osteoprotegerin
Abstract :
[en] The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlightedmore and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood,many questions still remain unanswered. This reviewbriefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
EVRARD, Séverine ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs Biologie Clinique
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Kamel, S
Cristol, JP
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Language :
English
Title :
Vascular calcification: from pathophysiology to biomarkers
Publication date :
January 2015
Journal title :
Clinica Chimica Acta
ISSN :
0009-8981
eISSN :
1873-3492
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
438
Pages :
401-14
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 October 2014

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