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| Reference : Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicill... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Physical, chemical, mathematical & earth Sciences : Chemistry | |||
| http://hdl.handle.net/2268/17335 | |||
| Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicillin-Binding Proteins | |
| English | |
| Beck, Josephine [> > > >] | |
| Gharbi, Sonia [> > > >] | |
| Herteg-Fernea, Adriana [> > > >] | |
| Vercheval, Lionel [Université de Liège - ULg > > Centre d'ingénierie des protéines >] | |
Bebrone, Carine  [Université de Liège - ULg > > Centre d'ingénierie des protéines >] | |
| Lassaux, Patricia [Université de Liège - ULg > Département des sciences de la vie > Macromolécules biologiques >] | |
| Zervosen, Astrid [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Marchand-Brynaert, Jacqueline [> > > >] | |
| Jan-2009 | |
| European Journal of Organic Chemistry | |
| 1 | |
| 85-97 | |
| International | |
| 1434-193X | |
| [en] aminophosphonic acid ; penicillin-binding protein ; beta-lactamase ; inhibitor | |
| [en] Abstract
Aminophosphonic acids and aminobis(phosphonic acids) have been prepared by the alkylation of Schiff bases with methyl bromoacetate or ethyl acrylate. Other pathways, like the modified Pudovik reaction and Kabachnik-Fields reaction, have been considered for the synthesis of the -phosphonic bioisoster of aminocitrate. Partial or complete deprotection of the phosphonate ester have been realised by either acidic hydrolysis or by treatment with trimethylsilyl bromide. Evaluation against penicillin-binding proteins has shown that our compounds are modest inhibitors of class A -lactamases, but have an interesting activity against R39 (D,D-peptidase/carboxypeptidase). | |
| Centre de Recherches du Cyclotron - CRC ; Centre d'Ingénierie des Protéines - CIP | |
| http://hdl.handle.net/2268/17335 | |
| 10.1002/ejoc.200800812 |
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