Biotechnological approaches to cassava protein improvement

Amino acids; Biotechnology; Carbohydrates; Nutrition; Plants (botany); Cassava protein; Malnutrition; Nutritional quality; Transgenic cassava; Proteins; Manihot esculenta

Abstract :

[en] Cassava starchy storage roots are an excellent source of carbohydrates but lacking in protein. To enhance their nutritional quality, here we discuss several biotechnological strategies that might be used to increase protein levels as well as improved essential amino acid content in transgenic cassava. Application of such strategies in this major crop could, in the long term, help to fight against malnutrition in those regions which depend heavily on cassava consumption. © 2006 Elsevier Ltd. All rights reserved.

Disciplines :

Phytobiology (plant sciences, forestry, mycology...)

Author, co-author :

Stupak, M.; Institute of Plant Sciences, ETH Zurich, Universitätstrasse 2, CH-8092 Zurich, Switzerland

Vanderschuren, Hervé ; Université de Liège - ULiège > Sciences agronomiques > Biologie végétale

Gruissem, W.; Institute of Plant Sciences, ETH Zurich, Universitätstrasse 2, CH-8092 Zurich, Switzerland

Zhang, P.; Institute of Plant Sciences, ETH Zurich, Universitätstrasse 2, CH-8092 Zurich, Switzerland, Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, 200032 Shanghai, China

Title :

Biotechnological approaches to cassava protein improvement

Publication date :

2006

Journal title :

Trends in Food Science and Technology

ISSN :

0924-2244

eISSN :

1879-3053

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

634-641

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 October 2014

Statistics

Number of views

77 (5 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Anderson J.W. Sulfur metabolism in plants. In: Miflin B., Lea P., Conn P., and Stumpf W. (Eds). Biochemistry of plants (1990), Academic Press, San Diego 327-381
Awoyinka A.F., Abegunde V.O., and Adewusi S.R. Nutrient content of young cassava leaves and assessment of their acceptance as a green vegetable in Nigeria. Plant Foods for Human Nutrition 47 (1995) 21-28
Bartlem D., Lambein I., Okamoto T., Itaya A., Uda Y., Kijima F., et al. Mutation in the threonine synthase gene results in an over-accumulation of soluble methionine in Arabidopsis. Plant Physiology 123 (2000) 101-110
Bellucci M., De Marchis F., Mannucci R., Bock R., and Arcioni S. Cytoplasm and chloroplasts are not suitable subcellular locations for beta-zein accumulation in transgenic plants. Journal of Experimental Botany 56 (2005) 1205-1212
Boerjan W., Bauw G., Van Montagu M., and Inze D. Distinct phenotypes generated by overexpression and suppression of S-adenosyl-l-methionine synthetase reveal developmental patterns of gene silencing in tobacco. Plant Cell 6 (1994) 1401-1414
Bokanga M. Processing of cassava leaves for human consumption. Acta Horticulturae 375 (1994) 203-208
Bryan J. Synthesis of the aspartate family and branched-chain amino acids. In: Miflin B. (Ed). The biochemistry of plants: A comprehensive treatise (1980), Academic Press, New York 403-452
Cai D.G., Thurau T., Tian Y.Y., Lange T., Yeh K.W., and Jung C. Sporamin-mediated resistance to beet cyst nematodes (Heterodera schachtii Schm.) is dependent on trypsin inhibitory activity in sugar beet (Beta vulgaris L.) hairy roots. Plant Molecular Biology 51 (2003) 839-849
Capell T., and Christou P. Progress in plant metabolic engineering. Current Opinion in Biotechnology 15 (2004) 148-154
Chakraborty S., Chakraborty N., and Datta A. Increased nutritive value of transgenic potato by expressing a nonallergenic seed albumin gene from Amaranthus hypochondriacus. Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 3724-3729
Chiaiese P., Ohkama-Ohtsu N., Molvig L., Godfree R., Dove H., Hocart C., et al. Sulphur and nitrogen nutrition influence the response of chickpea seeds to an added, transgenic sink for organic sulphur. Journal of Experimental Botany 55 (2004) 1889-1901
Cliff J., Lundqvist P., Martensson J., Rosling H., and Sorbo B. Association of high cyanide and low sulphur intake in cassava-induced spastic paraparesis. Lancet 2 (1985) 1211-1213
Cock J.H. Cassava-a basic energy-source in the tropics. Science 218 (1982) 755-762
Cohen G.N., and Saint-Girons I. Biosynthesis of threonine, lysine and methionine. In: Neidhardt F.C., Curtis III R., Ingraham J.L., Lin E.C.C., Low K.B., Magasanik B., Reznikoff W.S., Riley M., Schaechter M., and Umbarger H.E. (Eds). Escherichia coli and Salmonella typhimurium: Cellular and molecular biology (1987), American Society of Microbiology, Washington 429-444
Conlan R.S., Griffiths L.A., Napier J.A., Shewry P.R., Mantell S., and Ainsworth C. Isolation and characterization of cDNA clones representing the genes encoding the major tuber storage protein (dioscorin) of yam (Dioscorea cayenensis Lam.). Plant Molecular Biology 28 (1995) 369-380
Conlan S., Griffiths L.A., Turner M., Fido R., Tatham A., Ainsworth C., et al. Characterisation of the yam tuber storage protein dioscorin. Journal of Plant Physiology 153 (1998) 25-31
Curien G., Dumas R., Ravanel S., and Douce R. Characterization of an Arabidopsis thaliana cDNA encoding an S-adenosylmethionine-sensitive threonine synthase. Threonine synthase from higher plants. FEBS Letters 390 (1996) 85-90
De Clercq A., Vandewiele M., Vandamme J., Guerche P., Van Montagu M., Vandekerckhove J., et al. Stable accumulation of modified 2S albumin seed storage proteins with higher methionine contents in transgenic plants. Plant Physiology 94 (1990) 970-979
De Jaeger G., Scheffer S., Jacobs A., Zambre M., Zobell O., Goossens A., et al. Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences. Nature Biotechnology 20 (2002) 1265-1268
Delumen B.O., Thompson S., and Odegard W.J. Sulfur amino acid-rich proteins in acha (Digitaria exilis), a promising underutilized African cereal. Journal of Agricultural and Food Chemistry 41 (1993) 1045-1047
Denecke J., De Rycke R., and Botterman J. Plant and mammalian sorting signals for protein retention in the endoplasmic reticulum contain a conserved epitope. EMBO Journal 11 (1992) 2345-2355
De Souza C.R., Carvalho L.J., De Almeida E.R., and Gander E.S. Towards the identification of cassava root protein genes. Plant Foods for Human Nutrition 57 (2002) 353-363
De Souza C.R., Carvalho L.J., and de Mattos Cascardo J.C. Comparative gene expression study to identify genes possibly related to storage root formation in cassava. Protein and Peptide Letters 11 (2004) 577-582
Ding L.C., Hu C.Y., Yeh K.W., and Wang P.J. Development of insect-resistant transgenic cauliflower plants expressing the trypsin inhibitor gene isolated from local sweet potato. Plant Cell Reports 17 (1998) 854-860
Eggum B.O. Protein quality of cassava leaves. British Journal of Nutrition 24 (1970) 761-768
El-Sharkawy M.A., Hernandez A.D., and Hershey C. Yield stability of cassava during prolonged mid-season water-stress. Experimental Agriculture 28 (1992) 165-174
Falco S.C., Guida T., Locke M., Mauvais J., Sanders C., Ward R.T., et al. Transgenic canola and soybean seeds with increased lysine. Bio-Technology 13 (1995) 577-582
FAO. Protein quality evaluation. Joint FAO/WHO. FAO Food and Nutrition Paper 51 (1991) 1-66
FAO (2003). Faostat data. http://apps.fao.org/faostat/.
FAO. Agricultural biotechnology meeting the needs of the poor? (2004), Food and Agriculture Organization of the United Nations FAO
FAO. Faostat data (2005). http://apps.fao.org/faostat/
Franche C., Bogusz D., Schopke C., Fauquet C., and Beachy R.N. Transient gene-expression in cassava using high-velocity microprojectiles. Plant Molecular Biology 17 (1991) 493-498
Friedman M. Nutritional value of proteins from different food sources. A review. Journal of Agricultural and Food Chemistry 44 (1996) 6-29
Gaidamashvili M., Ohizumi Y., Iijima S., Takayama T., Ogawa T., and Muramoto K. Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities. Journal of Biological Chemistry 279 (2004) 26028-26035
Galili G. Regulation of lysine and threonine synthesis. Plant Cell 7 (1995) 899-906
Galili G., Amir R., Hoefgen R., and Hesse H. Improving the levels of essential amino acids and sulfur metabolites in plants. Biological Chemistry 386 (2005) 817-831
Galili G., and Hofgen R. Metabolic engineering of amino acids and storage proteins in plants. Metabolic Engineering 4 (2002) 3-11
Glenz K., Bouchon B., Stehle T., Wallich R., Simon M.M., and Warzecha H. Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. Nature Biotechnology 24 (2006) 76-77
Gomez G., and Noma A.T. The amino-acid-composition of cassava leaves, foliage, root tissues and whole-root chips. Nutrition Reports International 33 (1986) 595-601
Hadlington J.L., and Denecke J. Sorting of soluble proteins in the secretory pathway of plants. Current Opinion in Plant Biology 3 (2000) 461-468
Hagan N.D., Upadhyaya N., Tabe L.M., and Higgins T.J. The redistribution of protein sulfur in transgenic rice expressing a gene for a foreign, sulfur-rich protein. Plant Journal 34 (2003) 1-11
Hesse H., Kreft O., Maimann S., Zeh M., and Hoefgen R. Current understanding of the regulation of methionine biosynthesis in plants. Journal of Experimental Botany 55 (2004) 1799-1808
Hou W.C., Lee M.H., Chen H.J., Liang W.L., Han C.H., Liu Y.W., et al. Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Deene.) tuber. Journal of Agricultural and Food Chemistry 49 (2001) 4956-4960
Islam N., Upadhyaya N.M., Campbell P.M., Akhurst R., Hagan N., and Higgins T.J. Decreased accumulation of glutelin types in rice grains constitutively expressing a sunflower seed albumin gene. Phytochemistry 66 (2005) 2534-2539
Jideani I.A. Traditional and possible technological uses of Digitaria exilis (acha) and Digitaria iburua (iburu): A review. Plant Foods for Human Nutrition 54 (1999) 363-374
Karchi H., Shaul O., and Galili G. Seed-specific expression of a bacterial desensitized aspartate kinase increases the production of seed threonine and methionine in transgenic tobacco. Plant Journal 3 (1993) 721-727
Karchi H., Shaul O., and Galili G. Lysine synthesis and catabolism are coordinately regulated during tobacco seed development. Proceedings of the National Academy of Sciences of the United States of America 91 (1994) 2577-2581
Keeler S.J., Maloney C.L., Webber P.Y., Patterson C., Hirata L.T., Falco S.C., et al. Expression of de novo high-lysine alpha-helical coiled-coil proteins may significantly increase the accumulated levels of lysine in mature seeds of transgenic tobacco plants. Plant Molecular Biology 34 (1997) 15-29
Kim J., Cetiner S., and Jaynes J.M. Enhancing the nutritional quality of crop plants: Design, construction and expression of an artificial plant storage protein gene. In: Bhatnagar D., and Cleveland T.E. (Eds). Molecular approaches to improving food quality and safety (1992), Van Nostrand Reinhold, New York 1-36
Kortt A.A., Caldwell J.B., Lilley G.G., and Higgins T.J. Amino acid and cDNA sequences of a methionine-rich 2S protein from sunflower seed (Helianthus annuus l.). European Journal of Biochemistry 195 (1991) 329-334
Lancaster P.A., and Brooks J.E. Cassava leaves as human food. Economic Botany 37 (1983) 331-348
Liu D.Z., Lin Y.S., and Hou W.C. Monohydroxamates of aspartic acid and glutamic acid exhibit antioxidant and angiotensin converting enzyme inhibitory activities. Journal of Agricultural and Food Chemistry 52 (2004) 2386-2390
Maeshima M., Sasaki T., and Asahi T. Characterization of major proteins in sweet-potato tuberous roots. Phytochemistry 24 (1985) 1899-1902
Mainieri D., Rossi M., Archinti M., Bellucci M., De Marchis F., Vavassori S., et al. Zeolin. A new recombinant storage protein constructed using maize gamma-zein and bean phaseolin. Plant Physiology 136 (2004) 3447-3456
Matthews B. Lysine, threonine, and methionine biosynthesis. In: Singh B. (Ed). Plant amino acids: Biochemistry and biotechnology (1999), Marcel Dekker, New York 205-225
Mazur B., Krebbers E., and Tingey S. Gene discovery and product development for grain quality traits. Science 285 (1999) 372-375
Millward D.J. The nutritional value of plant-based diets in relation to human amino acid and protein requirements. Proceedings of the Nutrition Society 58 (1999) 249-260
Molvig L., Tabe L.M., Eggum B.O., Moore A.E., Craig S., Spencer D., et al. Enhanced methionine levels and increased nutritive value of seeds of transgenic lupins (Lupinus angustifolius L.) expressing a sunflower seed albumin gene. Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 8393-8398
Ngudi D.D., Kuo Y.H., and Lambein F. Food safety and amino acid balance in processed cassava "cossettes". Journal of Agricultural and Food Chemistry 50 (2002) 3042-3049
Ngudi D.D., Kuo Y.H., and Lambein F. Amino acid profiles and protein quality of cooked cassava leaves or 'saka-saka'. Journal of the Science of Food and Agriculture 83 (2003) 529-534
Nikiforova V., Kempa S., Zeh M., Maimann S., Kreft O., Casazza A.P., et al. Engineering of cysteine and methionine biosynthesis in potato. Amino Acids 22 (2002) 259-278
Odell J.T., Nagy F., and Chua N.H. Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter. Nature 313 (1985) 810-812
Raemakers C.J.J.M., Sofiari E., Taylor N., Henshaw G., Jacobsen E., and Visser R.G.F. Production of transgenic cassava (Manihot esculenta crantz) plants by particle bombardment using luciferase activity as selection marker. Molecular Breeding 2 (1996) 339-349
Raina A., and Datta A. Molecular cloning of a gene encoding a seed-specific protein with nutritionally balanced amino acid composition from Amaranthus. Proceedings of the National Academy of Sciences of the United States of America 89 (1992) 11774-11778
Rosling H. Measuring effects in humans of dietary cyanide exposure from cassava. Acta Horticulturae 375 (1994) 271-284
Schmidt R.J., Ketudat M., Aukerman M.J., and Hoschek G. Opaque-2 is a transcriptional activator that recognizes a specific target site in 22-kd-zein genes. Plant Cell 4 (1992) 689-700
Segal G., Song R., and Messing J. A new opaque variant of maize by a single dominant RNA-interference-inducing transgene. Genetics 165 (2003) 387-397
Shaul O., and Galili G. Increased lysine synthesis in tobacco plants that express high-levels of bacterial dihydrodipicolinate synthase in their chloroplasts. Plant Journal 2 (1992) 203-209
Sheffield J., Taylor N., Fauquet C., and Chen S. The cassava (Manihot esculenta Crantz) root proteome: Protein identification and differential expression. Proteomics 6 (2006) 1588-1598
Shen B., Li C., and Tarczynski M.C. High free-methionine and decreased lignin content result from a mutation in the Arabidopsis S-adenosyl-l-methionine synthetase 3 gene. Plant Journal 29 (2002) 371-380
Shewry P.R. Tuber storage proteins. Annals of Botany 91 (2003) 755-769
Siritunga D., Arias-Garzon D., White W., and Sayre R.T. Over-expression of hydroxynitrile lyase in transgenic cassava roots accelerates cyanogenesis and food detoxification. Plant Biotechnology Journal 2 (2004) 37-43
Siritunga D., and Sayre R. Engineering cyanogen synthesis and turnover in cassava (Manihot esculenta). Plant Molecular Biology 56 (2004) 661-669
Siritunga D., and Sayre R.T. Generation of cyanogen-free transgenic cassava. Planta 217 (2003) 367-373
Streatfield S.J., Lane J.R., Brooks C.A., Barker D.K., Poage M.L., Mayor J.M., et al. Corn as a production system for human and animal vaccines. Vaccine 21 (2003) 812-815
Tabe L., Hagan N., and Higgins T.J. Plasticity of seed protein composition in response to nitrogen and sulfur availability. Current Opinion in Plant Biology 5 (2002) 212-217
Taylor N., Chavarriaga P., Raemakers K., Siritunga D., and Zhang P. Development and application of transgenic technologies in cassava. Plant Molecular Biology 56 (2004) 671-688
USDA. U.S. Department of agriculture, agricultural research service. National nutrient database for standard reference, release 18. In Nutrient Data Laboratory home page (2005). http://www.nal.usda.gov/fnic/foodcomp
van den Hout R., Pouw M., Gruppen H., and van't Riet K. Inactivation kinetics study of the kunitz soybean trypsin inhibitor and the bowman-birk inhibitor. Journal of Agricultural and Food Chemistry 46 (1998) 281-285
Wallace J.C., Galili G., Kawata E.E., Cuellar R.E., Shotwell M.A., and Larkins B.A. Aggregation of lysine-containing zeins into protein bodies in Xenopus oocytes. Science 240 (1988) 662-664
Wang S.J., Lan Y.C., Chen S.F., Chen Y.M., and Yeh K.W. Wound-response regulation of the sweet potato sporamin gene promoter region. Plant Molecular Biology 48 (2002) 223-231
Yang J., Barr L.A., Fahnestock S.R., and Liu Z.B. High yield recombinant silk-like protein production in transgenic plants through protein targeting. Transgenic Research 14 (2005) 313-324
Yeh K.W., Lin M.I., Tuan S.J., Chen Y.M., Lin C.Y., and Kao S.S. Sweet potato (Ipomoea batatas) trypsin inhibitors expressed in transgenic tobacco plants confer resistance against Spodoptera litura. Plant Cell Reports 16 (1997) 696-699
Yeoh H.H., and Chew M.Y. Protein-content and amino-acid composition of cassava leaf. Phytochemistry 15 (1976) 1597-1599
Yeoh H.H., and Chew M.Y. Protein content and acid composition of cassava seed and tuber. Malaysian Agricultural Journal 51 (1977) 1-6
Yeoh H.H., and Paul K. Variation in leaf protein contents and amino-acid compositions of cassava cultivars. Biochemical Systematics and Ecology 17 (1989) 199-202
Zeh M., Casazza A.P., Kreft O., Roessner U., Bieberich K., Willmitzer L., et al. Antisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants. Plant Physiology 127 (2001) 792-802
Zhang P., Bohl-Zenger S., Puonti-Kaerlas J., Potrykus I., and Gruissem W. Two cassava promoters related to vascular expression and storage root formation. Planta 218 (2003) 192-203
Zhang P., and Gruissem W. Production of transgenic cassava (Manihot esculenta Crantz). In: Curtis I.S. (Ed). Transgenic crops of the world-Essential protocols (2004), Kluwer Academic, The Netherlands 301-319
Zhang P., Jaynes J.M., Potrykus I., Gruissem W., and Puonti-Kaerlas J. Transfer and expression of an artificial storage protein (asp1) gene in cassava (Manihot esculenta Crantz). Transgenic Research 12 (2003) 243-250
Zhang P., Legris G., Coulin P., and Puonti-Kaerlas J. Production of stably transformed cassava plants via particle bombardment. Plant Cell Reports 19 (2000) 939-945
Zhu X., and Galili G. Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds. Plant Cell 15 (2003) 845-853
Zhu X.H., and Galili G. Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues. Plant Physiology 135 (2004) 129-136