Reference : Biointerface multiparametric study of intraocular lens acrylic materials.
Scientific journals : Article
Human health sciences : Ophthalmology
http://hdl.handle.net/2268/172643
Biointerface multiparametric study of intraocular lens acrylic materials.
English
Bertrand, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Bozukova, Dimitriya [PhysIOL > > > >]
Svaldo Lanero, Tiziana [Université de Liège - ULg > Département de Chimie > NanoChemistry and Molecular Systems Laboratory > >]
Huang, Yi-Shiang mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Schol, Daureen [> >]
Rosière, Nancy mailto [Université de Liège - ULg > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
Grauwels, Magda mailto [Université de Liège - ULg > > Clinique des grands animaux (chirurgie) >]
Duwez, Anne-Sophie mailto [Université de Liège - ULg > Département de chimie (sciences) > Nanochimie et systèmes moléculaires >]
Jérôme, Christine mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM) >]
Pagnoulle, Christophe [PhysIOL sa > > > >]
De Pauw, Edwin mailto [Université de Liège - ULg > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
2014
Journal of cataract and refractive surgery
40
9
1536-44
Yes (verified by ORBi)
International
0886-3350
1873-4502
New York
NY
[en] Intraocular lens ; biocompatibility ; PCO
[en] PURPOSE: To compare hydrophilic and hydrophobic acrylic materials designed for intraocular lenses in a multiparametric investigation in a liquid environment to highlight their properties in terms of adhesion forces, lens epithelial cell (LEC) adhesion, and tissue response as indicators of the risk for posterior capsule opacification (PCO) development. SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: The hydrophobicity and surface adhesion force were assessed using contact-angle and atomic force microscopy measurements. The bioadhesiveness of the disks and the tissue response were determined by in vitro experiments using bovine serum albumin and porcine LECs and by in vivo rabbit subcutaneous implantation, respectively. RESULTS: Increasing surface hydrophobicity led to a greater surface-adhesion force and greater LEC adhesion. After 1 month, the rabbit subcutaneous implants showed a similar thin layer of fibrous capsule surrounding the disks without extensive inflammation. A layer of rounded cells in contact with disks was detected on the hydrophobic samples only. CONCLUSIONS: Hydrophobic acrylic disks that have been associated with a reduced risk for PCO in clinical studies showed increased tackiness. FINANCIAL DISCLOSURES: Proprietary or commercial disclosures are listed after the references.
Center for Education and Research on Macromolecules (CERM)
Researchers ; Professionals
http://hdl.handle.net/2268/172643
also: http://hdl.handle.net/2268/173367
10.1016/j.jcrs.2014.01.035
Copyright (c) 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

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