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Application of dual cyclodextrin systems in capillary electrophoresis enantioseparations.
Servais, Anne-Catherine; Fillet, Marianne
2013In Methods in Molecular biology 970: Chiral Separations
 

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Keywords :
Carbazoles/analysis/chemistry; Electrophoresis, Capillary/methods; Hydrogen-Ion Concentration; Models, Theoretical; Pentobarbital/analysis/chemistry; Stereoisomerism; beta-Cyclodextrins/analysis/chemistry
Abstract :
[en] The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual CD systems made up of a negatively charged CD derivative, i.e., sulfobutyl-beta-CD (SB-beta-CD) or carboxymethyl-beta-CD (CM-beta-CD), in combination with a neutral one, namely, heptakis(2,3,6-tri-O-methyl)-beta-CD (TM-beta-CD). An acidic compound (carprofen) and a weakly acidic drug (pentobarbital) were selected as model compounds.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Servais, Anne-Catherine  ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Application of dual cyclodextrin systems in capillary electrophoresis enantioseparations.
Publication date :
2013
Main work title :
Methods in Molecular biology 970: Chiral Separations
Publisher :
Springer, United States
Pages :
289-95
Available on ORBi :
since 25 September 2014

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