ORBi: Touchon M. - Transcription-coupled TA and GC strand asymmetries in the human genome

Reference : Transcription-coupled TA and GC strand asymmetries in the human genome


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Mathematics
	To cite this reference:	http://hdl.handle.net/2268/1722

Title :	Transcription-coupled TA and GC strand asymmetries in the human genome
Language :	English
Author, co-author :	Touchon, M. [> >]
	Nicolay, Samuel [Université de Liège - ULg > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes >]
	Arneodo, Alain [> >]
	d'Aubenton-Carafa [> >]
	Thermes, C. [> >]
Publication date :	2003
Journal title :	FEBS Letters
Publisher :	Elsevier Science
Volume :	555
Pages :	579-582
Audience :	International
ISSN :	0014-5793
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Skewness ; Strand asymmetry ; Mutation bias
Abstract :	[en] Abstract Analysis of the whole set of human genes reveals that most of them present TA and GC skews, that these biases are correlated to each other and are speci¢c to gene sequences, exhibiting sharp transitions between transcribed and non-tran- scribed regions. The GC asymmetries cannot be explained solely by a model previously proposed for (G+T) skew based on tran- sitions measured in a small set of human genes. We propose that the GC skew results from additional transcription-coupled mu- tation process that would include transversions. During evolu- tion, both processes acting on a large majority of genes in germ- line cells would have produced these transcription-coupled strand asymmetries.
Permalink :	http://hdl.handle.net/2268/1722
DOI :	10.1016/S0014-5793(03)01306-1

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