Unpublished conference/Abstract (Scientific congresses and symposiums)
Structural identifiability analysis of a cardiovascular system model
Pironet, Antoine; Dauby, Pierre; Chase, J. Geoffrey et al.
201419th World Congress of the International Federation of Automatic Control
 

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Keywords :
Quantification of physiological parameters for diagnosis and treatment assessment; Identification and validation; Biomedical system modeling, simulation and visualization
Abstract :
[en] A simple experimentally validated cardiovascular system model has been shown to be able to track the evolution of various diseases. The model has previously been made patient-specific by adjustment of its parameters on the basis of a minimal set of hemodynamic measurements. However, this model has not yet been shown to be structurally identifiable, which means that the adjusted model parameters may not be unique. The model equations were manipulated to show that, from a theoretical point of view, all of their parameters can be exactly retrieved from a restricted set of model outputs. However, this set of model outputs is still too large for a clinical application, because it includes left and right ventricular pressures. Consequently, further hypotheses that determine some model parameter values have to be made for the model to be clinically applicable.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Cardiovascular & respiratory systems
Author, co-author :
Pironet, Antoine ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Dauby, Pierre  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Chase, J. Geoffrey
Revie, James A.
Docherty, Paul D.
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Structural identifiability analysis of a cardiovascular system model
Publication date :
August 2014
Event name :
19th World Congress of the International Federation of Automatic Control
Event date :
du 24 au 29 août 2014
By request :
Yes
Audience :
International
Available on ORBi :
since 08 September 2014

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