Reference : Voxel-based analysis of confounding effects of age and dementia severity on cerebral met...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/1718
Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease
English
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. > > >]
Collette, Fabienne [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie > > >]
Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Franck, Georges [ > > ]
2000
Human brain mapping
Wiley Liss, Inc.
10
1
39-48
Yes (verified by ORBi)
International
1065-9471
1097-0193
New York
NY
[en] PET ; Dementia ; age
[fr] cingulate ; precuneus
[en] Alzheimer's disease is characterized by early hippocampal lesions, but neuropathological and functional imaging studies have also demonstrated involvement of associative cortices in patients suffering from this illness. New image-processing technologies have led to demonstration of predominant posteromedial cortical metabolic impairment in the disease. Confounding effects of both age and dementia severity on brain metabolism were assessed using categorical and correlational analyses performed with Statistical Parametric Mapping. Posterior cingulate and precuneus metabolism, assessed by positron emission tomography, was significantly correlated with age in a population of 46 patients with probable Alzheimer's disease. Metabolism in posterior cingulate and precuneus was higher in elderly than in younger patients with a diagnosis of Alzheimer's disease, even when dementia severity was taken as a confounding covariate. The data suggest that the sensitivity of positron emission tomography for the diagnosis of Alzheimer's disease is reduced in elderly cases, where less severe pathology is sufficient to induce clinical symptoms of dementia. Conversely, higher posteromedial metabolic impairment in early onset cases may reflect greater density of regional cerebral lesions or major decrease of functional afferences in a richly connected multimodal associative area. Posterior cingulate metabolism was also correlated to dementia severity, even when age was taken as a confounding covariate, whereas metabolism in the hippocampal formation was not shown to correlate with global cognitive deficit. Functional correlation was maintained between posterior cingulate and middle frontal cortex in demented patients as in elderly controls. The key role of posteromedial cortex in cognitive dysfunction assessed in Alzheimer's disease is probably related to its highly integrated position within attentional, visuospatial and memory neuronal networks.
Centre de Recherches du Cyclotron
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/1718
10.1002/(SICI)1097-0193(200005)10:1<39::AID-HBM50>3.0.CO;2-B
http://www3.interscience.wiley.com/journal/71008030/abstract

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.